Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Identifying damage clusters in patients with systemic lupus erythematosus

Authors
Ahn, Ga YoungLee, JiyoungWon, SoyoungHa, EunjiKim, HyoungyoungNam, BoraKim, Ji SoongKang, JuyeonKim, Jae-HoonSong, Gwan GyuKim, KwangwooBae, Sang-Cheol
Issue Date
1월-2020
Publisher
WILEY
Keywords
cluster analysis; genetic risk score; mortality; organ damage; SLEDAI; systemic lupus erythematosus
Citation
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.23, no.1, pp.84 - 91
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Volume
23
Number
1
Start Page
84
End Page
91
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/130739
DOI
10.1111/1756-185X.13745
ISSN
1756-1841
Abstract
Aim Systemic lupus erythematosus (SLE) causes irreversible damage to organ systems. Recently, evidence has been obtained for subphenotypes of SLE. This study aimed to identify damage clusters and compare the associated clinical manifestations, SLE disease activity, mortality, and genetic risk scores (GRS). Methods The study was conducted on the Hanyang BAE lupus cohort. Patients with disease duration k-means cluster analysis. Results Among the 1130 analyzed patients, musculoskeletal damage was most prevalent (20.2%), followed by ocular (11.4%), renal (10.5%), and neuropsychiatric damage (10.2%). Three significantly different damage clusters were identified. Patients in cluster 1 (n = 824) showed the least damage. Cluster 2 (n = 195) was characterized by frequent renal (55.4%) and ocular (58.0%) damage, and cluster 3 (n = 111) was dominated by neuropsychiatric (100%) and musculoskeletal damage (35.1%). Cluster 2 had the highest adjusted mean AMS (adjusted mean SLE Disease Activity Index score; mean +/- SD: 5.4 +/- 2.9), while cluster 3 had the highest mortality (14.4%). Weighted GRS did not differ significantly between the clusters. Conclusion Patients in prevalent renal and ocular damage cluster had the highest AMS scores, while the cluster with frequent neuropsychiatric damage had the highest mortality.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Gwan Gyu photo

Song, Gwan Gyu
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE