Differential synapse density between Purkinje cell dendritic spine and parallel fiber varicosity in the rat cerebellum among the phylogenic lobulesDifferential synapse density between Purkinje cell dendritic spine and parallel fiber varicosity in the rat cerebellum among the phylogenic lobules
- Other Titles
- Differential synapse density between Purkinje cell dendritic spine and parallel fiber varicosity in the rat cerebellum among the phylogenic lobules
- Authors
- 김현욱; Seung Hak Oh; 이세정; Ji eun Na; 유임주
- Issue Date
- 2020
- Publisher
- 한국현미경학회
- Keywords
- Cerebellum; Synapse; Phylogeny; Evolution
- Citation
- 한국현미경학회지, v.50, no.1, pp.1 - 6
- Indexed
- KCI
- Journal Title
- 한국현미경학회지
- Volume
- 50
- Number
- 1
- Start Page
- 1
- End Page
- 6
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/130959
- DOI
- 10.1186/s42649-020-00027-6
- ISSN
- 2287-5123
- Abstract
- The cerebellum is a region of the brain that plays an important role in motor control. It is classified phylogenetically into archicerebellum, paleocerebellum and neocerebellum. The Purkinje cells are lined in a row called Purkinje cell layer and it has a unique dendritic branches with many spines.
The previous study reported that there is a difference of synapse density according to the lobules based on large two-dimensional data. However, recent study with high voltage electron microscopy showed there was no differences in dendritic spine density of the Purkinje cell according to its phylogenetic lobule. We analyzed Purkinje cell density in the II, VI and X lobules by stereological modules and synaptic density was estimated by double disector based on Purkinje cell density in the molecular layer of each lobule.
The results showed that there was significant difference in the Purkinje cell density and synapse number according to their phylogenetic lobules. The number of Purkinje cell in a given volume was larger in the archicerebellum, but synapse density was higher in the neocerebellum.
These data suggest that cellular and synaptic organization of the Purkinje cell is different according to their phylogenetic background.
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