Risk factors for type-specific persistence of high-risk human papillomavirus and residual/recurrent cervical intraepithelial neoplasia after surgical treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오영택 | - |
dc.contributor.author | 조현웅 | - |
dc.contributor.author | 김성민 | - |
dc.contributor.author | 민경진 | - |
dc.contributor.author | 이상훈 | - |
dc.contributor.author | 송재윤 | - |
dc.contributor.author | 이재관 | - |
dc.contributor.author | 이낙우 | - |
dc.contributor.author | 홍진화 | - |
dc.date.accessioned | 2021-12-13T02:42:04Z | - |
dc.date.available | 2021-12-13T02:42:04Z | - |
dc.date.created | 2021-08-31 | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2287-8580 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/131198 | - |
dc.description.abstract | ObjectiveThis study aimed to investigate the clinicopathologic risk factors for type-specific persistence of high-risk humanpapillomavirus (hrHPV) and residual/recurrent cervical intraepithelial neoplasia (CIN) after surgical treatment. MethodsPatients with CIN-2/3 who underwent conization or loop electrosurgical excision procedure (LEEP) at Korea UniversityHospital were enrolled. All patients underwent hrHPV testing and genotyping before conization or LEEP followed byboth hrHPV genotyping and cytology. The significance of associations between patient characteristics and persistenceof infection were assessed by multivariate logistic regression analyses. ResultsAmong 398 women with pathologically confirmed CIN-2/3, 154 (38.7%) patients showed hrHPV persistence aftersurgical treatment. In multivariate analysis, high preoperative hrHPV load (P<0.05; odds ratio [OR], 2.063), presenceof CIN-2 at treatment (P<0.01; OR, 2.732), and multiple hrHPV infections (P<0.001; OR, 4.752) were associated withhrHPV persistence. HPV 53 was the most likely to persist after treatment (24/43, 55.8%). The risk of residual/recurrentCIN-2/3 was higher in persistent infection with HPV 16 than other types (P<0.05). Menopause (P<0.001; OR, 3.969),preoperative and postoperative hrHPV load (P<0.05; OR, 2.430; P<0.05; OR, 5.351), and infection with multiple hrHPVtypes (P<0.05; OR, 2.345) were significantly related to residual/recurrent CIN following surgical treatment. ConclusionHPV load before treatment and infection with multiple hrHPV types were predictors of postoperative hrHPVpersistence. HPV 53 was the type most likely to persist, but HPV 16 was the type that was most closely associated withresidual/recurrent CIN-2/3. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한산부인과학회 | - |
dc.title | Risk factors for type-specific persistence of high-risk human papillomavirus and residual/recurrent cervical intraepithelial neoplasia after surgical treatment | - |
dc.title.alternative | Risk factors for type-specific persistence of high-risk human papillomavirus and residual/recurrent cervical intraepithelial neoplasia after surgical treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 홍진화 | - |
dc.identifier.doi | 10.5468/ogs.20049 | - |
dc.identifier.scopusid | 2-s2.0-85091012916 | - |
dc.identifier.bibliographicCitation | Obstetrics & Gynecology Science, v.63, no.5, pp.631 - 642 | - |
dc.relation.isPartOf | Obstetrics & Gynecology Science | - |
dc.citation.title | Obstetrics & Gynecology Science | - |
dc.citation.volume | 63 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 631 | - |
dc.citation.endPage | 642 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002625107 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Cervical intraepithelial neoplasia | - |
dc.subject.keywordAuthor | Conization | - |
dc.subject.keywordAuthor | Human papillomavirus | - |
dc.subject.keywordAuthor | HPV DNA tests | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.