Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
DC Field | Value | Language |
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dc.contributor.author | Hur, Gyu Young | - |
dc.contributor.author | Broide, David H. | - |
dc.date.accessioned | 2021-12-13T21:42:21Z | - |
dc.date.available | 2021-12-13T21:42:21Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/131389 | - |
dc.description.abstract | Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling is characterized by structural changes which include airway smooth muscle hypertrophy/hyperplasia, subepithelial fibrosis due to thickening of the reticular basement membrane, mucus metaplasia of the epithelium, and angiogenesis. Epidemiologic studies suggest that both genetic and environmental factors may contribute to decline in lung function and airway remodeling in a subset of asthmatics. Environmental factors include respiratory viral infection-triggered asthma exacerbations, and tobacco smoke. There is also evidence that several asthma candidate genes may contribute to decline in lung function, including ADAM33, PLAUR, VEGF, IL13, CHI3L1, TSLP, GSDMB, TGFB1, POSTN, ESR1 and ARG2. In addition, mediators or cytokines, including cysteinyl leukotrienes, matrix metallopeptidase-9, interleukin-33 and eosinophil expression of transforming growth factor-beta, may contribute to airway remodeling in asthma. Although increased airway smooth muscle is associated with reduced lung function (i.e. forced expiratory volume in 1 second) in asthma, there have been few long-term studies to determine how individual pathologic features of airway remodeling contribute to decline in lung function in asthma. Clinical studies with inhibitors of individual gene products, cytokines or mediators are needed in asthmatic patients to identify their individual role in decline in lung function and/or airway remodeling. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | GENOMEWIDE ASSOCIATION | - |
dc.subject | SEVERE EXACERBATIONS | - |
dc.subject | BASEMENT-MEMBRANE | - |
dc.subject | CHILDHOOD ASTHMA | - |
dc.subject | FLOW LIMITATION | - |
dc.subject | ADAM33 GENE | - |
dc.subject | TGF-BETA | - |
dc.subject | INFLAMMATION | - |
dc.subject | POLYMORPHISMS | - |
dc.title | Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hur, Gyu Young | - |
dc.identifier.doi | 10.4168/aair.2019.11.5.604 | - |
dc.identifier.scopusid | 2-s2.0-85072045981 | - |
dc.identifier.wosid | 000476653700003 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.11, no.5, pp.604 - 621 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 604 | - |
dc.citation.endPage | 621 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002498712 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | GENOMEWIDE ASSOCIATION | - |
dc.subject.keywordPlus | SEVERE EXACERBATIONS | - |
dc.subject.keywordPlus | BASEMENT-MEMBRANE | - |
dc.subject.keywordPlus | CHILDHOOD ASTHMA | - |
dc.subject.keywordPlus | FLOW LIMITATION | - |
dc.subject.keywordPlus | ADAM33 GENE | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordAuthor | Airway remodeling | - |
dc.subject.keywordAuthor | gene polymorphisms | - |
dc.subject.keywordAuthor | lung function tests | - |
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