Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jangili, Paramesh | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Kim, Seo Jin | - |
dc.contributor.author | Chun, Jieun | - |
dc.contributor.author | Shim, Inseob | - |
dc.contributor.author | Kang, Chulhun | - |
dc.contributor.author | Ren, Wen Xiu | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-12-13T23:00:24Z | - |
dc.date.available | 2021-12-13T23:00:24Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2019-08-19 | - |
dc.identifier.issn | 2576-6422 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/131398 | - |
dc.description.abstract | We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5'-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, Miae | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/acsabm.9b00418 | - |
dc.identifier.scopusid | 2-s2.0-85071663942 | - |
dc.identifier.wosid | 000616371100040 | - |
dc.identifier.bibliographicCitation | ACS APPLIED BIO MATERIALS, v.2, no.8, pp.3532 - 3539 | - |
dc.relation.isPartOf | ACS APPLIED BIO MATERIALS | - |
dc.citation.title | ACS APPLIED BIO MATERIALS | - |
dc.citation.volume | 2 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3532 | - |
dc.citation.endPage | 3539 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordAuthor | binary drug | - |
dc.subject.keywordAuthor | SN-38 | - |
dc.subject.keywordAuthor | 5&apos | - |
dc.subject.keywordAuthor | -DFUR | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | synergistic effect | - |
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