Frequency and Severity of Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with a Sulfonylurea-Based Regimen at University-Affiliated Hospitals in Korea: The Naturalistic Evaluation of Hypoglycemic Events in Diabetic Subjects Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Cho, Be Long | - |
dc.contributor.author | Kim, Woo Sik | - |
dc.contributor.author | Kim, Sang Hyun | - |
dc.contributor.author | Jung, In Hyeon | - |
dc.contributor.author | Sin, Won Yong | - |
dc.contributor.author | Choi, Dong Hoon | - |
dc.contributor.author | Lee, Sang Jae | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kang, Kyung Pyo | - |
dc.contributor.author | Yu, Byung Yeon | - |
dc.contributor.author | Jeung, Wonju | - |
dc.contributor.author | Park, Chang Gyu | - |
dc.date.accessioned | 2021-12-14T00:00:16Z | - |
dc.date.available | 2021-12-14T00:00:16Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 2005-6443 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/131408 | - |
dc.description.abstract | Background: We assessed the frequency and severity of hypoglycemia in type 2 diabetes mellitus patients treated with sulfonylurea monotherapy or sulfonylurea+metformin. Methods: We conducted a retrospective, observational, cross-sectional study in 2011 and 2012 including patients with type 2 diabetes mellitus aged >= 30 years who were treated with >= 6 months of sulfonylurea monotherapy or sulfonylurea+metformin at 20 university-affiliated hospitals in Korea. At enrollment, glycated hemoglobin (HbA1c) was assessed; participants completed self-reported questionnaires describing hypoglycemia incidents over the past 6 months. A review of medical records up to 12 months before enrollment provided data on demographics, disease history, comorbidities, laboratory results, and drug usage. Results: Of 726 enrolled patients, 719 were included (55.6% male); 31.7% and 68.3% were on sulfonylurea monotherapy and sulfonylurea+metformin, respectively. Mean +/- standard deviation age was 65.9 +/- 10.0 years; mean HbA1c level was 7.0%+/- 1.0%; 77.8% of patients had hypertension (89.4% used antihypertensive medication); 60.5% had lipid disorders (72.5% used lipid-lowering medication); and 52.0% had one or more micro- or macrovascular diseases. Among patients with A1c measurement (n=717), 56.4% achieved therapeutic goals (HbA1c <7.0%); 42.4% (305/719) experienced hypoglycemia within 6 months of enrollment; and 38.8%, 12.9%, 12.7%, and 3.9% of patients experienced mild, moderate, severe, and very severe hypoglycemia symptoms, respectively. Several reported hypoglycemia frequency as 1-2 times over the last 6 months. The mean number of very severe hypoglycemia episodes was 3.5 +/- 5.5. Conclusion: Among type 2 diabetes mellitus patients treated with sulfonylurea-based regimens, glycemic levels were relatively well controlled but hypoglycemia remained a prevalent side effect. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD FAMILY MEDICINE | - |
dc.subject | REAL-LIFE EFFECTIVENESS | - |
dc.subject | CARE PATTERNS | - |
dc.subject | MANAGEMENT | - |
dc.subject | MORTALITY | - |
dc.subject | GLUCOSE | - |
dc.subject | DRUGS | - |
dc.subject | RISK | - |
dc.title | Frequency and Severity of Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with a Sulfonylurea-Based Regimen at University-Affiliated Hospitals in Korea: The Naturalistic Evaluation of Hypoglycemic Events in Diabetic Subjects Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Chang Gyu | - |
dc.identifier.doi | 10.4082/kjfm.18.0051 | - |
dc.identifier.scopusid | 2-s2.0-85069763308 | - |
dc.identifier.wosid | 000487848000003 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF FAMILY MEDICINE, v.40, no.4, pp.212 - 219 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF FAMILY MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF FAMILY MEDICINE | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 212 | - |
dc.citation.endPage | 219 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002487968 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Primary Health Care | - |
dc.subject.keywordPlus | REAL-LIFE EFFECTIVENESS | - |
dc.subject.keywordPlus | CARE PATTERNS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Glycated Hemoglobin A | - |
dc.subject.keywordAuthor | Hypoglycemia | - |
dc.subject.keywordAuthor | Sulfonylurea | - |
dc.subject.keywordAuthor | Type 2 Diabetes Mellitus | - |
dc.subject.keywordAuthor | Metformin | - |
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