Postneonatal Mortality and Liver Changes in Cloned Pigs Associated with Human Tumor Necrosis Factor Receptor I-Fc and Human Heme Oxygenase-1 Overexpression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Geon A. | - |
dc.contributor.author | Jin, Jun-Xue | - |
dc.contributor.author | Lee, Sanghoon | - |
dc.contributor.author | Taweechaipaisankul, Anukul | - |
dc.contributor.author | Oh, Hyun Ju | - |
dc.contributor.author | Hwang, Joing-Ik | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Saadeldin, Islam M. | - |
dc.contributor.author | Lee, Byeong Chun | - |
dc.date.accessioned | 2021-12-21T16:40:50Z | - |
dc.date.available | 2021-12-21T16:40:50Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/132427 | - |
dc.description.abstract | Soluble human tumor necrosis factor (shTNFRI-Fc) and human heme oxygenase 1 (hHO-1) are key regulators for protection against oxidative and inflammatory injury for xenotransplantation. Somatic cells with more than 10 copy numbers of shTNFRI-Fc and hHO-1 were employed in somatic cell nuclear transfer to generate cloned pigs, thereby resulting in seven cloned piglets. However, produced piglets were all dead within 24 hours after birth. Obviously, postnatal death with liver apoptosis was reported in the higher copy number of shTNFRI-Fc and hHO-1 piglets. In liver, the transcript levels of ferritin heavy chain, light chain, transferrin, and inducible nitric oxide synthase were significantly highly expressed compared to those of lower copy number of shTNFRI-Fc and hHO-1 piglets (P < 0.05). Also, H2O2 contents were increased, and superoxide dismutase was significantly lower in the higher copy number of shTNFRI-Fc and hHO-1 piglets (P < 0.05). These results indicate that TNFRI-Fc and hHO-1 overexpression may apparently induce free iron in the liver and exert oxidative stress by enhancing reactive oxygen species production and block normal postneonatal liver metabolism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | MICE LACKING TYPE-1 | - |
dc.subject | EX-VIVO PERFUSION | - |
dc.subject | LABILE IRON POOL | - |
dc.subject | COPY NUMBER | - |
dc.subject | TNF-ALPHA | - |
dc.subject | FERRITIN | - |
dc.subject | GENE | - |
dc.subject | INJURY | - |
dc.subject | TRANSGENE | - |
dc.subject | REGENERATION | - |
dc.title | Postneonatal Mortality and Liver Changes in Cloned Pigs Associated with Human Tumor Necrosis Factor Receptor I-Fc and Human Heme Oxygenase-1 Overexpression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Joing-Ik | - |
dc.identifier.doi | 10.1155/2017/5276576 | - |
dc.identifier.scopusid | 2-s2.0-85018942351 | - |
dc.identifier.wosid | 000399970600001 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2017 | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2017 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | MICE LACKING TYPE-1 | - |
dc.subject.keywordPlus | EX-VIVO PERFUSION | - |
dc.subject.keywordPlus | LABILE IRON POOL | - |
dc.subject.keywordPlus | COPY NUMBER | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | FERRITIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | TRANSGENE | - |
dc.subject.keywordPlus | REGENERATION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.