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High Prevalence of Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women

Authors
Seo, Sang SooArokiyaraj, SelvarajKim, Mi KyungOh, Hea YoungKwon, MinjiKong, Ji SookShin, Moon KyungYu, Ye LeeLee, Jae Kwan
Issue Date
2017
Publisher
HINDAWI LTD
Citation
BIOMED RESEARCH INTERNATIONAL, v.2017
Indexed
SCIE
SCOPUS
Journal Title
BIOMED RESEARCH INTERNATIONAL
Volume
2017
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/132443
DOI
10.1155/2017/5435089
ISSN
2314-6133
Abstract
Objective. Thepurpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women. Methods. We collected cervical swabs from women who had never undergone abortion (N= 36), had spontaneous abortion (N = 23), and had undergone induced abortion (N= 88) and subjected those samples to 16S rRNA pyrosequencing. Further, factor analysis and correlation between cervical microbiota and spontaneous abortion were evaluated by logistic regression analysis. Results. In spontaneous abortion women, 16 S rRNA gene sequences showed significant increases in Atopobium vaginae, Megasphaera spp., Gardnerella vaginalis, Leptotrichia amnionii, and Sneathia sanguinegens compared to women in nonabortion group. In multivariate logistic regression analysis, A. vaginae (OD = 11.27; 95% = 1.57-81), L. amnionii (OD = 11.47; 95% = 1.22-107.94), S. sanguinegens (OD = 6.89; 95% = 1.07-44.33), and factor 1 microbes (OD = 16.4; 95% = 1.88-42.5) were strongly associated with spontaneous abortion. Conclusions. This study showed a high prevalence of L. amnionii, A. vaginae, S. sanguinegens, and factor 1 microbes in spontaneous abortion and association with spontaneous abortion in Korean women.
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