Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Seung-In | - |
dc.contributor.author | Lim, Ji Yeon | - |
dc.contributor.author | Yoo, Sungjae | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Hwang, Sun Wook | - |
dc.date.accessioned | 2021-12-24T00:40:40Z | - |
dc.date.available | 2021-12-24T00:40:40Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2090-5904 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/132706 | - |
dc.description.abstract | TRPV1 is well known as a sensor ion channel that transduces a potentially harmful environment into electrical depolarization of the peripheral terminal of the nociceptive primary afferents. Although TRPV1 is also expressed in central regions of the nervous system, its roles in the area remain unclear. A series of recent reports on the spinal cord synapses have provided evidence that TRPV1 plays an important role in synaptic transmission in the pain pathway. Particularly, in pathologic pain states, TRPV1 in the central terminal of sensory neurons and interneurons is suggested to commonly contribute to pain exacerbation. These observations may lead to insights regarding novel synaptic mechanisms revealing veiled roles of spinal cord TRPV1 and may offer another opportunity to modulate pathological pain by controlling TRPV1. In this review, we introduce historical perspectives of this view and details of the recent promising results. We also focus on extended issues and unsolved problems to fully understand the role of TRPV1 in pathological pain. Together with recent findings, further efforts for fine analysis of TRPV1's plastic roles in pain synapses at different levels in the central nervous system will promote a better understanding of pathologic pain mechanisms and assist in developing novel analgesic strategies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | SUBSTANTIA-GELATINOSA NEURONS | - |
dc.subject | VANILLOID RECEPTOR TRPV1 | - |
dc.subject | DORSAL-ROOT GANGLION | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | SYNAPTIC-TRANSMISSION | - |
dc.subject | MECHANICAL ALLODYNIA | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | BEHAVIORAL HYPERSENSITIVITY | - |
dc.subject | INFLAMMATORY HYPERALGESIA | - |
dc.subject | DIFFERENTIAL EXPRESSION | - |
dc.title | Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.contributor.affiliatedAuthor | Hwang, Sun Wook | - |
dc.identifier.doi | 10.1155/2016/5954890 | - |
dc.identifier.scopusid | 2-s2.0-84962723909 | - |
dc.identifier.wosid | 000371497500001 | - |
dc.identifier.bibliographicCitation | NEURAL PLASTICITY, v.2016 | - |
dc.relation.isPartOf | NEURAL PLASTICITY | - |
dc.citation.title | NEURAL PLASTICITY | - |
dc.citation.volume | 2016 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SUBSTANTIA-GELATINOSA NEURONS | - |
dc.subject.keywordPlus | VANILLOID RECEPTOR TRPV1 | - |
dc.subject.keywordPlus | DORSAL-ROOT GANGLION | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | SYNAPTIC-TRANSMISSION | - |
dc.subject.keywordPlus | MECHANICAL ALLODYNIA | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | BEHAVIORAL HYPERSENSITIVITY | - |
dc.subject.keywordPlus | INFLAMMATORY HYPERALGESIA | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.