Effects of End-Terminal Capping on Transthyretin (105-115) Amyloid Protofibrils Using Steered Molecular Dynamics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Myeongsang | - |
dc.contributor.author | Choi, Hyunsung | - |
dc.contributor.author | Na, Sungsoo | - |
dc.date.accessioned | 2021-12-24T00:41:23Z | - |
dc.date.available | 2021-12-24T00:41:23Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1687-4110 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/132708 | - |
dc.description.abstract | Numerous degenerative diseases are associated with amyloidosis, which can be caused by amyloid proteins. These amyloid proteins are generated from misfolded and denatured amyloid monomers under physiological conditions. Changes in protonation state, pH, ionic strength, and temperature, in addition tomutations, are related to the promotion of amyloidosis. Specifically, an understanding of the mechanical characteristics of amyloid protofibrils is important, since amyloid growth proceeds by a mechanism involving cycles of fragmentation and elongation. However, there remains a lack of knowledge of amyloid structural conformations and their mechanical characteristics, particularly considering end-terminal capping effects. In the present study, we investigated the mechanical characteristics of transthyretin amyloid protein (TTR), which have been implicated in cardiovascular disease, and specifically considered the contribution of end-terminal capping effects. Using steered molecular dynamics (SMD) simulations, we report different structural behaviors between uncapped and capped TTR amyloid protofibrils. We show that end-terminal capping strengthens the structural stability and improves the mechanical properties of amyloid protofibrils. This study provides useful information concerning the structural and mechanical characteristics of TTR amyloid protofibrils, with a particular emphasis on end-terminal capping effects. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | MECHANICAL-PROPERTIES | - |
dc.subject | STRUCTURAL CHARACTERISTICS | - |
dc.subject | FIBRILS | - |
dc.subject | PEPTIDE | - |
dc.subject | BETA(2)-MICROGLOBULIN | - |
dc.subject | STABILITY | - |
dc.subject | OLIGOMERS | - |
dc.subject | RESIDUES | - |
dc.subject | FAILURE | - |
dc.title | Effects of End-Terminal Capping on Transthyretin (105-115) Amyloid Protofibrils Using Steered Molecular Dynamics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.1155/2016/1863065 | - |
dc.identifier.scopusid | 2-s2.0-84973160628 | - |
dc.identifier.wosid | 000376909600001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOMATERIALS, v.2016 | - |
dc.relation.isPartOf | JOURNAL OF NANOMATERIALS | - |
dc.citation.title | JOURNAL OF NANOMATERIALS | - |
dc.citation.volume | 2016 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | MECHANICAL-PROPERTIES | - |
dc.subject.keywordPlus | STRUCTURAL CHARACTERISTICS | - |
dc.subject.keywordPlus | FIBRILS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | BETA(2)-MICROGLOBULIN | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | OLIGOMERS | - |
dc.subject.keywordPlus | RESIDUES | - |
dc.subject.keywordPlus | FAILURE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.