Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
DC Field | Value | Language |
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dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwon, Tae Gyun | - |
dc.contributor.author | Kim, Hyeon Hoe | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Kim, Yong-June | - |
dc.contributor.author | Lee, Won Ki | - |
dc.date.accessioned | 2021-12-24T04:40:35Z | - |
dc.date.available | 2021-12-24T04:40:35Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/132726 | - |
dc.description.abstract | Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. Theobjective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated. Results. Patients with higher NLR had larger tumors (p < 0.001), higher T stage (p < 0.001), worse Eastern Cooperative Oncology Group performance status (p < 0.001), worse symptoms (p = 0.003), sarcomatoid differentiation (p = 0.004), and tumor necrosis ( p < 0.001). The 5-year RFS and CSS rates were significantly lower in patients with high NLR than in those with low NLR (each p < 0.001). Multivariate analysis identified NLR to be an independent predictor of RFS and CSS (each p < 0.05). Moreover, predictive accuracy of multivariate models for RFS and CSS increased by 2.2% and 4.2%, respectively, withNLR inclusion. Conclusions. Higher NLR was associated with worse clinical behavior of non-mRCC. Also, NLR was a significant prognostic factor of both RFS and CSS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | SYSTEMIC INFLAMMATORY RESPONSE | - |
dc.subject | PRETREATMENT NEUTROPHIL | - |
dc.subject | FOLLOW-UP | - |
dc.subject | SURVIVAL | - |
dc.subject | PREDICTOR | - |
dc.subject | CANCER | - |
dc.subject | IMPACT | - |
dc.title | Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.1155/2016/5634148 | - |
dc.identifier.scopusid | 2-s2.0-84998727420 | - |
dc.identifier.wosid | 000388385800001 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2016 | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2016 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | SYSTEMIC INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | PRETREATMENT NEUTROPHIL | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IMPACT | - |
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