Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Nam-Ho | - |
dc.contributor.author | Lee, So-Hyoun | - |
dc.contributor.author | Ryu, Jae-Jun | - |
dc.contributor.author | Choi, Kyung-Hee | - |
dc.contributor.author | Huh, Jung-Bo | - |
dc.date.accessioned | 2021-12-26T11:41:00Z | - |
dc.date.available | 2021-12-26T11:41:00Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/133199 | - |
dc.description.abstract | This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design. Methods. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1mg/mL). After assessment of surface characteristics and rhBMP-2 releasing profile, the experimental groups and untreated control groups (n = 6 in each group, two animals in each group) were placed in split-mouth designed animal models with buccal open defect. At 8 weeks after implant placement, implant stability quotients (ISQ) values were recorded and vertical bone height (VBH, mm), bone-to-implant contact ratio (BIC, %), and bone volume (BV, %) in the upper 3mm defect areas were measured. Results. The ISQ values were highest in the 1.0 group. Mean values of VBH (mm), BIC (%), and BV (%) were greater in the 0.5mg/mL and 1.0mg/mL groups than those in 0.1 and control groups in buccal defect areas. Conclusion. In the open defect area surrounding the SLA implant, coating with 0.5 and 1.0mg/mL concentrations of rhBMP-2 was more effective, compared with untreated group, in promoting bone regeneration and osseointegration. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | COLI-DERIVED RHBMP-2 | - |
dc.subject | MORPHOGENETIC PROTEIN-2 | - |
dc.subject | ANODIZED IMPLANTS | - |
dc.subject | CHONDROITIN SULFATE | - |
dc.subject | MARGINAL PORTION | - |
dc.subject | DENTAL IMPLANTS | - |
dc.subject | BMP | - |
dc.subject | DEFECTS | - |
dc.subject | IMMOBILIZATION | - |
dc.subject | INTEGRATION | - |
dc.title | Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-Jun | - |
dc.identifier.doi | 10.1155/2015/459393 | - |
dc.identifier.scopusid | 2-s2.0-84945293126 | - |
dc.identifier.wosid | 000363133400001 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2015 | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2015 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | COLI-DERIVED RHBMP-2 | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | ANODIZED IMPLANTS | - |
dc.subject.keywordPlus | CHONDROITIN SULFATE | - |
dc.subject.keywordPlus | MARGINAL PORTION | - |
dc.subject.keywordPlus | DENTAL IMPLANTS | - |
dc.subject.keywordPlus | BMP | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | INTEGRATION | - |
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