CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-12-26T19:32:08Z | - |
dc.date.available | 2021-12-26T19:32:08Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/133267 | - |
dc.description.abstract | Objective: The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). Methods: The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, 318 C/T, CT60 A/C polymorphisms, and (AT)n repeat in the 3' untranslated region (UTR) and UC and CD susceptibility. Results: A total of 15 comparison studies were considered in our meta-analysis. Meta-analysis revealed no association between UC and the CTLA-4 +49 G and CTLA-4-318 T alleles in all subjects (OR = 0.982, 95% CI = 0.851-1.1339, p = 0.804; OR = 0.500, 95% CI = 0.223-1.124, p = 0.094). No association was found between UC and the CTLA-4 CT60 A/C polymorphism in Europeans. However, a significant association was observed between the longer allele (>= 118 bp) of the (AT)n and UC in Asian population (OR = 6.073, 95% CI = 4.246-8.684, p = 1.0 x 10 x 10(-9)). Meta-analysis of the CTLA-4 +49 A/G, 318 CIT. CT60 A/C polymorphisms showed no association with CD. Conclusions: This meta-analysis demonstrates that the CTLA-4 (AT)n repeat in 3' UTR may be associated with susceptibility to UC in Asians, while no association was found between the CTLA-4 +49 A/G, -318 C/T, and CD60 A/G polymorphism and susceptibility to UC and CD. (C) 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | ULCERATIVE-COLITIS | - |
dc.subject | GENE POLYMORPHISM | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | CHINESE PATIENTS | - |
dc.subject | CROHNS-DISEASE | - |
dc.subject | ASSOCIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | VARIANTS | - |
dc.subject | REGION | - |
dc.title | CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1016/j.humimm.2014.02.020 | - |
dc.identifier.scopusid | 2-s2.0-84896548089 | - |
dc.identifier.wosid | 000333728100002 | - |
dc.identifier.bibliographicCitation | HUMAN IMMUNOLOGY, v.75, no.5, pp.414 - 421 | - |
dc.relation.isPartOf | HUMAN IMMUNOLOGY | - |
dc.citation.title | HUMAN IMMUNOLOGY | - |
dc.citation.volume | 75 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 414 | - |
dc.citation.endPage | 421 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CHINESE PATIENTS | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | REGION | - |
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