Association between TNF-alpha promoter-308 A/G polymorphism and rheumatoid arthritis: a meta-analysis
- Authors
- Song, Gwan Gyu; Bae, Sang-Cheol; Kim, Jae-Hoon; Lee, Young Ho
- Issue Date
- 4월-2014
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Tumor necrosis factor; Polymorphism; Rheumatoid arthritis; Meta-analysis
- Citation
- RHEUMATOLOGY INTERNATIONAL, v.34, no.4, pp.465 - 471
- Indexed
- SCIE
SCOPUS
- Journal Title
- RHEUMATOLOGY INTERNATIONAL
- Volume
- 34
- Number
- 4
- Start Page
- 465
- End Page
- 471
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/133278
- DOI
- 10.1007/s00296-013-2919-5
- ISSN
- 0172-8172
- Abstract
- The aim of this study was to determine whether the tumor necrosis factor-alpha (TNF-alpha) promoter -308 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. MEDLINE and EMBASE databases and manual search were used to identify articles in which TNF-alpha polymorphism was determined in RA patients and controls. A meta-analysis was conducted on the associations between the TNF-alpha -308 A/G polymorphism and RA by using (1) allelic contrast and (2) dominant models. A total of 19 studies involving 2,584 RA patients and 3,254 controls were considered. The meta-analysis showed no association between the TNF-alpha -308 A allele and RA when all the subjects were considered [odds ratio (OR) = 1.129, 95 % CI 0.843-1.513, P = 0.416]. After stratification by ethnicity, the meta-analysis indicated that the A allele was significantly associated with RA in Latin Americans (OR = 1.620, 95 % CI 1.234-2.111, P = 3.6 x 10(-5)), but not in the European, Arab, or Asian populations. The meta-analysis of the AA/AG genotype showed the same pattern of results as with the A allele. No association was noted between the AA/AG genotype and RA when all the subjects were considered (OR = 1.114, 95 % CI 0.812-1.529, P = 0.503), but stratification by ethnicity revealed that the AA/AG genotype was significantly associated with RA in Latin Americans (OR = 1.650, 95 % CI 1.234-2.104, P = 0.001). This meta-analysis showed that the TNF-alpha -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans but not in the European, Arab, or Asian populations.
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