Implication of Lymph Node Metastasis Detected on F-18-FDG PET/CT for Surgical Planning in Patients With Peripheral Intrahepatic Cholangiocarcinoma
- Authors
- Park, Tae Gyu; Yu, Young-Dong; Park, Beom Jin; Cheon, Gi Jeong; Oh, Sun Young; Kim, Dong-Sik; Choe, Jae-Gol
- Issue Date
- 1월-2014
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- peripheral intrahepatic cholangiocarcinoma; lymph node metastasis; F-18-FDG PET/CT; 1-year recurrence
- Citation
- CLINICAL NUCLEAR MEDICINE, v.39, no.1, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL NUCLEAR MEDICINE
- Volume
- 39
- Number
- 1
- Start Page
- 1
- End Page
- 7
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/133286
- ISSN
- 0363-9762
- Abstract
- Objectives: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma. ICC can be divided into 2 types according to their location: peripheral and hilar types. Intense F-18-FDG uptake on PET was reported in peripheral ICC. However, the usefulness of PET/CT in detecting tumors and predicting prognosis in peripheral ICC has not been fully evaluated. In this study, we evaluated the clinical role of F-18-FDG PET/CT to predict the recurrence after the curative resection in patients with surgically indicated peripheral ICC. Methods: Eighteen patients with ICC underwent preoperative CT and F-18-FDG PET/CT scans. SUVmax of tumor, tumor to normal liver SUV ratio (TNR), lymph node status evaluated by F-18-FDG PET/CT, tumor and lymph node size measured by CT, vascular invasion confirmed by pathology, and satellite nodules found on CT were compared between 1-year recurrence group and recurrence-free group by chi-square test. Results: Of total 23 measurable lymph nodes, 4 nodes were positive and other 19 nodes were negative or equivocal on CT. Among those 23 nodes, 9 nodes were positive and other 14 nodes were negative on 18F-FDG PET/CT. The sensitivity and specificity of CT were 20.0% and 86.4%, and those of F-18-FDG PET/CT were 80.0% and 92.3%. In the comparison between 1-year recurrent and nonrecurrent groups, lymph node metastasis detected on F-18-FDG PET/CT had statistically positive correlation with the 1-year recurrence after surgical resection (P = 0.02). Other factors showed no statistically significant difference between the groups. Conclusion: We found that lymph node metastasis detected on F-18-FDG PET/CT correlated positively with 1-year recurrence after surgical resection in patients with peripheral ICC.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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