Does Prior Microsurgery Improve or Worsen the Outcomes of Stereotactic Radiosurgery for Cavernous Sinus Meningiomas?
DC Field | Value | Language |
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dc.contributor.author | Kano, Hideyuki | - |
dc.contributor.author | Park, Kyun-Jae | - |
dc.contributor.author | Kondziolka, Douglas | - |
dc.contributor.author | Iyer, Aditya | - |
dc.contributor.author | Liu, Xiaomin | - |
dc.contributor.author | Tonetti, Daniel | - |
dc.contributor.author | Flickinger, John C. | - |
dc.contributor.author | Lunsford, L. Dade | - |
dc.date.accessioned | 2021-12-29T01:59:28Z | - |
dc.date.available | 2021-12-29T01:59:28Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 0148-396X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/133550 | - |
dc.description.abstract | BACKGROUND: Stereotactic radiosurgery (SRS) is an important option for patients with cavernous sinus meningiomas. OBJECTIVE: To evaluate cranial nerve outcomes in patients who underwent SRS for cavernous sinus meningiomas with or without prior microsurgery. METHODS: During a 23-year interval, 272 patients underwent Gamma Knife SRS for cavernous sinus meningiomas (70 men, 202 women; median age, 54 years). In this series, 99 patients underwent prior microsurgical resection. The median tumor volume was 7.9 cm(3) and median marginal dose was 13 Gy. The median follow-up period was 62 months (range, 6-209 months). RESULTS: The progression-free survival after SRS was 96% at 3 years, 94% at 5 years, and 86% at 10 years. After SRS, 13 of 91 patients (14%) who underwent prior microsurgery had improvement of preexisting cranial nerve symptoms or signs. In comparison, 54 of 145 patients (37%) without prior microsurgery had improvement of preexisting cranial nerve symptoms or signs. The improvement rate of cranial nerve deficits after SRS in patients without prior microsurgery was 20% at 1 year, 34% at 2 years, 36% at 3 years, and 39% at 5 years. Patients who had not undergone prior microsurgery had significantly higher improvement rates of preexisting cranial nerve symptoms and signs (P = .001). After SRS, 29 patients (11%) developed new or worsened cranial nerve function. CONCLUSION: SRS provided long-term effective tumor control and a low risk of new cranial nerve deficits. Improvement in preexisting cranial neuropathies was detected in significantly more patients who had not undergone prior microsurgical procedures. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | GAMMA-KNIFE RADIOSURGERY | - |
dc.subject | TERM-FOLLOW-UP | - |
dc.subject | RADIATION-THERAPY | - |
dc.subject | SURGERY | - |
dc.subject | RADIOTHERAPY | - |
dc.subject | EXPERIENCE | - |
dc.subject | PROGRESSION | - |
dc.subject | MANAGEMENT | - |
dc.subject | RECURRENCE | - |
dc.subject | TUMORS | - |
dc.title | Does Prior Microsurgery Improve or Worsen the Outcomes of Stereotactic Radiosurgery for Cavernous Sinus Meningiomas? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyun-Jae | - |
dc.identifier.doi | 10.1227/01.neu.0000431471.64289.3d | - |
dc.identifier.scopusid | 2-s2.0-84883263184 | - |
dc.identifier.wosid | 000330385300013 | - |
dc.identifier.bibliographicCitation | NEUROSURGERY, v.73, no.3, pp.401 - 410 | - |
dc.relation.isPartOf | NEUROSURGERY | - |
dc.citation.title | NEUROSURGERY | - |
dc.citation.volume | 73 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 401 | - |
dc.citation.endPage | 410 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | GAMMA-KNIFE RADIOSURGERY | - |
dc.subject.keywordPlus | TERM-FOLLOW-UP | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordAuthor | Cavernous sinus | - |
dc.subject.keywordAuthor | Cranial nerve deficits | - |
dc.subject.keywordAuthor | Gamma Knife | - |
dc.subject.keywordAuthor | Meningioma | - |
dc.subject.keywordAuthor | Stereotactic radiosurgery | - |
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