Usefulness of thallium-201 SPECT for prediction of early progression in low-grade astrocytomas diagnosed by stereotactic biopsy
DC Field | Value | Language |
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dc.contributor.author | Park, Kyung-Jae | - |
dc.contributor.author | Kang, Shin-Hyuk | - |
dc.contributor.author | Park, Dong-Hyuk | - |
dc.contributor.author | Cho, Tai-Hyoung | - |
dc.contributor.author | Choe, Jae Gol | - |
dc.contributor.author | Chung, Yong-Gu | - |
dc.date.accessioned | 2021-12-31T16:58:50Z | - |
dc.date.available | 2021-12-31T16:58:50Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0303-8467 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/133865 | - |
dc.description.abstract | Objective: To establish the value of thallium-201 single-photon emission computed tomography (Tl-201-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs). Methods: We studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (Tl-201 index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients. Results: During a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7%). Based on Cox's proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, Tl-201 index > 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a Tl-201 index > 1.9 and a MIB-1 index > 6% were associated with short PFS. Conclusion: Tl-201 SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high Tl-201 uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination. (C) 2011 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | SURGICAL RESECTION | - |
dc.subject | PROGNOSTIC ASSESSMENT | - |
dc.subject | HEMISPHERIC GLIOMAS | - |
dc.subject | II ASTROCYTOMAS | - |
dc.subject | BRAIN-TUMORS | - |
dc.subject | SURVIVAL | - |
dc.subject | ADULTS | - |
dc.subject | MIB-1 | - |
dc.subject | EXTENT | - |
dc.subject | RECURRENCE | - |
dc.title | Usefulness of thallium-201 SPECT for prediction of early progression in low-grade astrocytomas diagnosed by stereotactic biopsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyung-Jae | - |
dc.contributor.affiliatedAuthor | Kang, Shin-Hyuk | - |
dc.contributor.affiliatedAuthor | Park, Dong-Hyuk | - |
dc.contributor.affiliatedAuthor | Cho, Tai-Hyoung | - |
dc.contributor.affiliatedAuthor | Choe, Jae Gol | - |
dc.identifier.doi | 10.1016/j.clineuro.2011.10.023 | - |
dc.identifier.scopusid | 2-s2.0-84857785576 | - |
dc.identifier.wosid | 000301814400005 | - |
dc.identifier.bibliographicCitation | CLINICAL NEUROLOGY AND NEUROSURGERY, v.114, no.3, pp.223 - 229 | - |
dc.relation.isPartOf | CLINICAL NEUROLOGY AND NEUROSURGERY | - |
dc.citation.title | CLINICAL NEUROLOGY AND NEUROSURGERY | - |
dc.citation.volume | 114 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 223 | - |
dc.citation.endPage | 229 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | SURGICAL RESECTION | - |
dc.subject.keywordPlus | PROGNOSTIC ASSESSMENT | - |
dc.subject.keywordPlus | HEMISPHERIC GLIOMAS | - |
dc.subject.keywordPlus | II ASTROCYTOMAS | - |
dc.subject.keywordPlus | BRAIN-TUMORS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | MIB-1 | - |
dc.subject.keywordPlus | EXTENT | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordAuthor | Biopsy | - |
dc.subject.keywordAuthor | Low-grade astrocytoma | - |
dc.subject.keywordAuthor | Progression-free survival | - |
dc.subject.keywordAuthor | Single-photon emission computed tomography | - |
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