Expression of SOCS1 and SOCS3 Is Altered in the Nasal Mucosa of Patients with Mild and Moderate/Severe Persistent Allergic Rhinitis
- Authors
- Kim, Tae Hoon; Kim, Kihyoung; Park, Se Jin; Lee, Seung Hoon; Hwang, Jae Woong; Park, Sang Heon; Yum, Gun Hwee; Lee, Sang Hag
- Issue Date
- 2012
- Publisher
- KARGER
- Keywords
- Allergic nasal mucosa; Healthy nasal mucosa; Persistent allergy; Rhinitis; SOCS1; SOCS3
- Citation
- INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, v.158, no.4, pp.387 - 396
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- Volume
- 158
- Number
- 4
- Start Page
- 387
- End Page
- 396
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/134192
- DOI
- 10.1159/000333103
- ISSN
- 1018-2438
- Abstract
- Background: The aim of this study was to evaluate the role of suppressor of cytokine signaling (SOCS) molecules, SOCS1 and SOCS3, which act as negative regulators of cytokine signaling in various allergic diseases, in patients with mild and moderate/severe persistent allergic rhinitis. Methods: The expression and distribution pattern of SOCS1 and SOCS3 were analyzed in nasal mucosa and peripheral blood mononuclear cells (PBMC) of healthy controls, and patients with mild and moderate/severe persistent allergic rhinitis using RT-PCR, immunohistochemistry and Western blotting. IL-4, IL-13, IL-15 and IFN-gamma expression was also analyzed in the nasal mucosa of each individual using RT-PCR and Western blotting. Results: SOCS1 and SOCS3 mRNA and protein expression was significantly increased in the nasal mucosa and PBMC of patients with mild and moderate/severe persistent allergic rhinitis compared with healthy controls. In healthy and allergic nasal mucosa, they were commonly localized to the epithelium, submucosal glands and endothelium, showing stronger staining intensity in mild and moderate/severe persistent allergic nasal mucosa than in healthy nasal mucosa. Tissue levels of IL-4 and IL-13 were increased in moderate/severe persistent allergic nasal mucosa whereas IL-15 and IFN-gamma were decreased in moderate/severe persistent allergic nasal mucosa. Conclusions: Upregulation of SOCS1 and SOCS3 in mild and moderate/severe persistent allergic rhinitis suggests that SOCS proteins may be important regulators in the pathogenesis of allergic rhinitis and play a role as molecular determinants of allergic rhinitis persistence. Copyright (C) 2012 S. Karger AG, Basel
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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