Anti-ischemic and anti-inflammatory activity of (S)-cis-verbenol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, In-Young | - |
dc.contributor.author | Lim, Ji H. | - |
dc.contributor.author | Hwang, Sunyoung | - |
dc.contributor.author | Lee, Jae-Chul | - |
dc.contributor.author | Cho, Geum-Sil | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.date.accessioned | 2022-01-05T09:41:18Z | - |
dc.date.available | 2022-01-05T09:41:18Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/134470 | - |
dc.description.abstract | (S)-cis-verbenol, a natural metabolite from (-)-alpha-pinene of host pine tree, has been suggested to have anti-ischemic activity. However, the exact mechanism for the anti-ischemic activity of (S)-cis-verbenol remains unclear yet. In the present study, (S)-cis-verbenol reduced cerebral ischemic injury caused by 1.5-h middle cerebral artery occlusion followed by 24-h reperfusion. Furthermore, (S)-cis-verbenol significantly prevented neuronal cell death caused by oxygen-glucose deprivation (OGD, 1 h) and subsequent re-oxygenation (5 h). While (S)-cis-verbenol did not inhibit the NMDA-stimulated calcium influx, it reduced the intracellular level of reactive oxygen species (ROS) elevated by OGD/re-oxygenation. ORAC assay indicated that (S)-cis-verbenol potently eliminated peroxyl radicals. In DPPH and DHR123 fluorescence assays, however, (S)-cis-verbenol did not show a direct ROS scavenging effect. Furthermore, (S)-cis-verbenol reduced the expression levels of pro-inflammatory cytokines in ischemic brain and immunostimulated glial cells. The present results indicate that (S)-cis-verbenol may be a useful therapeutic agent due to its anti-oxidative and anti-inflammatory activities. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.subject | RADICAL ABSORBENCY CAPACITY | - |
dc.subject | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject | GLUCOSE DEPRIVATION | - |
dc.subject | ANTIMICROBIAL ACTIVITY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | ESSENTIAL OILS | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | NEURONS | - |
dc.subject | STROKE | - |
dc.title | Anti-ischemic and anti-inflammatory activity of (S)-cis-verbenol | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, In-Young | - |
dc.contributor.affiliatedAuthor | Kim, Won-Ki | - |
dc.identifier.doi | 10.3109/10715761003667562 | - |
dc.identifier.scopusid | 2-s2.0-77951284579 | - |
dc.identifier.wosid | 000276815300007 | - |
dc.identifier.bibliographicCitation | FREE RADICAL RESEARCH, v.44, no.5, pp.541 - 551 | - |
dc.relation.isPartOf | FREE RADICAL RESEARCH | - |
dc.citation.title | FREE RADICAL RESEARCH | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 541 | - |
dc.citation.endPage | 551 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | RADICAL ABSORBENCY CAPACITY | - |
dc.subject.keywordPlus | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | GLUCOSE DEPRIVATION | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | ESSENTIAL OILS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordAuthor | (S)-cis-verbenol | - |
dc.subject.keywordAuthor | Infl ammation | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | OGD/re-oxygenation | - |
dc.subject.keywordAuthor | Peroxyl radicals | - |
dc.subject.keywordAuthor | ROS | - |
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