Expression pattern of the class I homeobox genes in ovarian carcinoma
DC Field | Value | Language |
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dc.contributor.author | Hong, Jin Hwa | - |
dc.contributor.author | Lee, Jae Kwan | - |
dc.contributor.author | Park, Joong Jean | - |
dc.contributor.author | Lee, Nak Woo | - |
dc.contributor.author | Lee, Kyu Wan | - |
dc.contributor.author | Na, Jung Yeol | - |
dc.date.accessioned | 2022-01-05T10:41:37Z | - |
dc.date.available | 2022-01-05T10:41:37Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 2005-0380 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/134476 | - |
dc.description.abstract | Objective: Although some sporadic reports reveal the link between the homeobox (HOX) genes and ovarian carcinoma, there is no comprehensive analysis of the expression pattern of the class 1 homeobox genes in ovarian carcinoma that determines the candidate genes involved in ovarian carcinogenesis. Methods: The different patterns of expression of 36 HOX genes were analyzed, including 4 ovarian cancer cell lines and 4 normal ovarian tissues. Using a reverse transcription-polymerase chain reaction (RT-PCR) and quantification analysis, the specific gene that showed a significantly higher expression in ovarian cancer cell lines than in normal ovaries was selected, and western blot analysis was performed adding 7 ovarian cancer tissue specimens. Finally, immunohistochemical and immunocytochemical analyses were performed to compare the pattern of expression of the specific HOX gene between ovarian cancer tissue and normal ovaries. Results: Among 36 genes, 11 genes had a different level of mRNA expression between the cancer cell lines and the normal ovarian tissues. Of the 11 genes, only HOXB4 had a significantly higher level of expression in ovarian cancer cell lines than in normal ovaries (p=0.029). Based on western blot, immunohistochemical, and immunocytochemical analyses, HOXB4 was expressed exclusively in the ovarian cancer cell lines or cancer tissue specimens, but not in the normal ovaries. Conclusion: We suggest HOXB4 may be a novel candidate gene involved in ovarian carcinogenesis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY | - |
dc.subject | IMMUNOCYTOCHEMICAL DETECTION | - |
dc.subject | ENDOMETRIAL ADENOCARCINOMA | - |
dc.subject | PRODUCT EXPRESSION | - |
dc.subject | CERVICAL-CARCINOMA | - |
dc.subject | CANCER CELLS | - |
dc.subject | HOX | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | LEUKEMIA | - |
dc.subject | MUTATION | - |
dc.subject | B4 | - |
dc.title | Expression pattern of the class I homeobox genes in ovarian carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jin Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Jae Kwan | - |
dc.contributor.affiliatedAuthor | Park, Joong Jean | - |
dc.contributor.affiliatedAuthor | Lee, Nak Woo | - |
dc.contributor.affiliatedAuthor | Lee, Kyu Wan | - |
dc.identifier.doi | 10.3802/jgo.2010.21.1.29 | - |
dc.identifier.scopusid | 2-s2.0-77953428228 | - |
dc.identifier.wosid | 000276175400006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GYNECOLOGIC ONCOLOGY, v.21, no.1, pp.29 - 37 | - |
dc.relation.isPartOf | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.title | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.endPage | 37 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001431025 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | PRODUCT EXPRESSION | - |
dc.subject.keywordPlus | CERVICAL-CARCINOMA | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | HOX | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | B4 | - |
dc.subject.keywordPlus | IMMUNOCYTOCHEMICAL DETECTION | - |
dc.subject.keywordPlus | ENDOMETRIAL ADENOCARCINOMA | - |
dc.subject.keywordAuthor | Homeobox gene | - |
dc.subject.keywordAuthor | Ovarian neoplasms | - |
dc.subject.keywordAuthor | Carcinogenesis | - |
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