Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity
DC Field | Value | Language |
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dc.contributor.author | Piao, Hua Zi | - |
dc.contributor.author | Choi, In Young | - |
dc.contributor.author | Park, Jin-Sun | - |
dc.contributor.author | Kim, Hee-Sun | - |
dc.contributor.author | Cheong, Jae Hoon | - |
dc.contributor.author | Son, Kun Ho | - |
dc.contributor.author | Jeon, Su Jin | - |
dc.contributor.author | Ko, Kwang Ho | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.date.accessioned | 2022-01-08T07:40:41Z | - |
dc.date.available | 2022-01-08T07:40:41Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2008-12-10 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/134842 | - |
dc.description.abstract | Previously, we and others have demonstrated that wogonin, an active component from the root of Scutellaria baicalensis Georgi, has a neuroprotective effect in cerebral ischemic insult. The neuroprotective effect of wogonin may at least in part be due to its anti-inflammatory properties. Microglial cells, well-known residential macrophages in the central nervous system, migrate to the ischemic lesion and play a pivotal role in the development of chronic inflammation. In the present study, we observed that wogonin potently inhibited microglial migration toward a chemokine, monocyte chemoattractant protein-1 (MCP-1). The anti-migratory effect of wogonin was provoked at nanomolar concentrations, at which wogonin did not significantly inhibit the production of cytokines and chemokines. NF-kappa B has previously shown to regulate microglial cell migration, and activation of cAMP-signaling pathway has also been associated with inhibition of microglial cell motility. in the present study, wogonin at low micromolar concentrations completely suppressed the activity of NF-kappa B in MCP-1-stimulated microglia, and NF-kappa B inhibitors such as N-acetyl cysteine and pyrroliclinedithiocarbamate inhibited the MCP-1-induced migration of microglial cells. However, wogonin did not stimulate the production of cAMP in microglial cells. Our results indicate that the anti-inflammatory activity of wogonin is exerted at least in part by suppressing microglial cell motility via inhibition of NF-kappa B activity. (c) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | FLAVONOID WOGONIN | - |
dc.subject | EPITHELIAL-CELL | - |
dc.subject | NEURONAL DEATH | - |
dc.subject | GLIAL-CELLS | - |
dc.subject | INFLAMMATION | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.title | Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, In Young | - |
dc.contributor.affiliatedAuthor | Kim, Won-Ki | - |
dc.identifier.doi | 10.1016/j.intimp.2008.07.018 | - |
dc.identifier.wosid | 000260805100009 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.8, no.12, pp.1658 - 1662 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 8 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1658 | - |
dc.citation.endPage | 1662 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | FLAVONOID WOGONIN | - |
dc.subject.keywordPlus | EPITHELIAL-CELL | - |
dc.subject.keywordPlus | NEURONAL DEATH | - |
dc.subject.keywordPlus | GLIAL-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Wogonin | - |
dc.subject.keywordAuthor | MCP-1 | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Migration | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | cAMP | - |
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