Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma
- Authors
- Seo, Yeon Seok; Kim, Jin Nam; Keum, Bora; Park, Sanghoon; Kwon, Yong Dae; Kim, Yong Sik; Jeen, Yoon Tae; Chun, Hoon Jai; Kim, Chul Yong; Kim, Chang Duck; Ryu, Ho Sang; Um, Soon Ho
- Issue Date
- 21-4월-2008
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- hepatocellular carcinoma; radiotherapy; treatment response; survival
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.14, no.15, pp.2394 - 2400
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 14
- Number
- 15
- Start Page
- 2394
- End Page
- 2400
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/134875
- DOI
- 10.3748/wjg.14.2394
- ISSN
- 1007-9327
- Abstract
- AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METHODS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage M and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate I mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, alpha-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m >= 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%. (c) 2008 WJG. All rights reserved.
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