Triazinyl architecture on bifunctional carboranyl templates for the production of potential neutron capture therapy agents: Synthesis and characterization of 1,3,5-triazinylcarborane derivatives
DC Field | Value | Language |
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dc.contributor.author | Lee, Chai-Ho | - |
dc.contributor.author | Jin, Guo Fan | - |
dc.contributor.author | Yoon, Ji Ho | - |
dc.contributor.author | Kim, Sun Hee | - |
dc.contributor.author | Lee, Jong-Dae | - |
dc.contributor.author | Nakamura, Hiroyuki | - |
dc.contributor.author | Kang, Sang Ook | - |
dc.date.accessioned | 2022-01-08T11:40:34Z | - |
dc.date.available | 2022-01-08T11:40:34Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2008-04-17 | - |
dc.identifier.issn | 0039-7881 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/134881 | - |
dc.description.abstract | A method for preparing triazinyl-substituted carboranyl systems using 1,2-, 1,7-, and 1,12-C2B10H12 as cores and [di(alkyl)amino]triazine as substituents is described. A sulfur-containing o-carboranyl cage compound was also incorporated into the 1,3,5-triazine network to generate new types of hybrid compounds having a thio-ether linkage. Within the series of synthesized compounds, one showed increased water solubility arising from the effective camouflaging of the central p-carboranyl unit by the polar functional groups at the periphery. Furthermore, the same compound exhibited high boron uptake in B-16 melanoma cells with low toxicity, showing promise as a BNCT agent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.subject | ANDROGEN RECEPTOR ANTAGONISTS | - |
dc.subject | HYDROPHOBIC CORE | - |
dc.subject | BORON | - |
dc.subject | LIPOSOMES | - |
dc.subject | CHEMISTRY | - |
dc.subject | EFFICIENT | - |
dc.subject | BEARING | - |
dc.subject | FACILE | - |
dc.subject | TUMORS | - |
dc.subject | RING | - |
dc.title | Triazinyl architecture on bifunctional carboranyl templates for the production of potential neutron capture therapy agents: Synthesis and characterization of 1,3,5-triazinylcarborane derivatives | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Sang Ook | - |
dc.identifier.doi | 10.1055/s-2008-1066983 | - |
dc.identifier.scopusid | 2-s2.0-43049083393 | - |
dc.identifier.wosid | 000255365400005 | - |
dc.identifier.bibliographicCitation | SYNTHESIS-STUTTGART, no.8, pp.1193 - 1200 | - |
dc.relation.isPartOf | SYNTHESIS-STUTTGART | - |
dc.citation.title | SYNTHESIS-STUTTGART | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1193 | - |
dc.citation.endPage | 1200 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR ANTAGONISTS | - |
dc.subject.keywordPlus | HYDROPHOBIC CORE | - |
dc.subject.keywordPlus | BORON | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | BEARING | - |
dc.subject.keywordPlus | FACILE | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | RING | - |
dc.subject.keywordAuthor | carborane scaffold | - |
dc.subject.keywordAuthor | mono(triazinyl)carborane | - |
dc.subject.keywordAuthor | bis(triazinyl)carborane | - |
dc.subject.keywordAuthor | o-carboranylthiolate | - |
dc.subject.keywordAuthor | triazine architecture | - |
dc.subject.keywordAuthor | water-solubility | - |
dc.subject.keywordAuthor | boron neutron capture therapy | - |
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