Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants

Authors
Lee, Hwa-YoungKim, Yong-Ku
Issue Date
2008
Publisher
KARGER
Keywords
brain-derived neurotrophic factor; major depressive disorder; antidepressant treatment
Citation
NEUROPSYCHOBIOLOGY, v.57, no.4, pp.194 - 199
Indexed
SCIE
SCOPUS
Journal Title
NEUROPSYCHOBIOLOGY
Volume
57
Number
4
Start Page
194
End Page
199
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/134982
DOI
10.1159/000149817
ISSN
0302-282X
Abstract
Numerous studies have demonstrated that depression is associated with a decreased expression of brain-derived neurotrophic factor (BDNF). BDNF shows antidepressant-like effects in animal models. Therefore, we tested the hypothesis that BDNF might be a peripheral marker for the mechanism of action of antidepressant agents in humans. Thirty-two patients meeting the DSM-IV criteria for major depressive disorder and 50 normal control subjects were recruited for this study. Plasma BDNF levels and Hamilton Depression Rating Scales were measured at baseline and 6 weeks after antidepressant administration. At baseline, the mean plasma BDNF level was lower in the depressive patients (698.1 +/- 537.7 pg/ml) than in the control subjects (830.7 +/- 624.8 pg/ml), although the difference was not statistically significant ( p = 0.33). The plasma BDNF levels in depressive patients significantly increased from 698.1 +/- 537.7 to 1,028.9 +/- 744.5 after 6 weeks of antidepressant treatment ( p = 0.01). Moreover, plasma BDNF levels were significantly increased after 6 weeks of treatment in the responder group, while there was no statistically significant change in the unresponsive group. These results suggest that the therapeutic response after antidepressant administration might be attributable to the increase in BDNF levels. BDNF may play a critical role in the action mechanism of antidepressant drugs. Further studies with a larger number of subjects are needed to verify these findings. Copyright (c) 2008 S. Karger AG, Basel.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Yong Ku photo

Kim, Yong Ku
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE