Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Juwhan Choi | - |
dc.contributor.author | Jee Youn Oh | - |
dc.contributor.author | Young Seok Lee | - |
dc.contributor.author | Kyung Hoon Min | - |
dc.contributor.author | Jae Jeong Shim | - |
dc.contributor.author | Sue In Choi | - |
dc.contributor.author | Dong Won Park | - |
dc.contributor.author | Chan Kwon Park | - |
dc.contributor.author | Eun Joo Kang | - |
dc.contributor.author | Hwan Seok Yong | - |
dc.contributor.author | Bong Kyung Shin | - |
dc.contributor.author | Hyun Koo Kim | - |
dc.contributor.author | Sung Yong Lee | - |
dc.date.accessioned | 2022-02-11T12:41:11Z | - |
dc.date.available | 2022-02-11T12:41:11Z | - |
dc.date.created | 2022-01-17 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135339 | - |
dc.description.abstract | Background/Aims: Adjuvant chemotherapy is the standard of care for resected stage II-IIIA non-small cell lung cancer (NCSLC). The efficacy of adjuvant chemotherapy in stage IB (< 4 cm) NSCLC with high-risk factors is controversial. Methods: This retrospective multicenter study included 285 stage IB NSCLC patients with high-risk factors according to the 8th edition tumor, node, metastasis (TNM) classification from four academic hospitals. High-risk factors included visceral pleural invasion, vascular invasion, lymphatic invasion, lung neuroendocrine tumors, and micropapillary histology patterns. Results: Of the 285 patients, 127 (44.6%) were included in the adjuvant chemotherapy group and 158 (55.4%) were included in the non-adjuvant chemotherapy group. The median follow-up was 41.5 months. Patients in the adjuvant chemotherapy group had a significantly reduced recurrence rate and risk of mortality than those in the non-adjuvant chemotherapy group (hazards ratio, 0.408; 95% confidence interval, 0.221 to 0.754; p = 0.004 and hazards ratio, 0.176; 95% confidence interval, 0.057 to 0.546; p = 0.003, respectively). Adjuvant chemotherapy should be particularly considered for the highrisk factors such as visceral pleural involvement or vascular invasion. Based on the subgroup analysis, adjuvant chemotherapy should be considered when visceral pleural involvement is present, even if the tumor size is < 3 cm. Conclusions: Adjuvant chemotherapy may be useful for patients with stage IB NSCLC with high-risk factors and is more relevant for patients with visceral pleural involvement or vascular invasion. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한내과학회 | - |
dc.title | Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors | - |
dc.title.alternative | Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jee Youn Oh | - |
dc.contributor.affiliatedAuthor | Sung Yong Lee | - |
dc.identifier.doi | 10.3904/kjim.2020.011 | - |
dc.identifier.scopusid | 2-s2.0-85102513333 | - |
dc.identifier.wosid | 000744160600014 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.37, no.1, pp.127 - 136 | - |
dc.relation.isPartOf | The Korean Journal of Internal Medicine | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 136 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002787601 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | VINORELBINE PLUS CISPLATIN | - |
dc.subject.keywordPlus | MICROPAPILLARY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | Carcinoma | - |
dc.subject.keywordAuthor | non-small-cell lung | - |
dc.subject.keywordAuthor | Surgery | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | adjuvant | - |
dc.subject.keywordAuthor | Risk factor | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.