ROS activated prodrug for ALDH overexpressed cancer stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Kim, Ji Hyeon | - |
dc.contributor.author | Ji, Myung Sun | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2022-02-11T22:40:20Z | - |
dc.date.available | 2022-02-11T22:40:20Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021-12-21 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135391 | - |
dc.description.abstract | Aldehyde dehydrogenase (ALDH), a cancer stem cell biomarker, is related to drug resistance. Co-treatment of anti-cancer drug (CPT) and ALDH inhibitor (DEAB) can overcome the drug resistance of cancer stem cells (CSCs) and finally cure cancers without relapse. We herein introduce a prodrug (DE-CPT) - consisting of 1,3-oxathiolane as an ROS responsive scaffold, and an aldehyde protecting group of DEAB - to deliver the CPT and DEAB upon reaction with ROS. From tests of the sphere-forming ability and CSC marker subpopulation, we found that DE-CPT efficiently decreases the CSCs population and kills the cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | ALDEHYDE DEHYDROGENASE ALDH | - |
dc.subject | MECHANISM | - |
dc.subject | DELIVERY | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | RESISTANCE | - |
dc.subject | SUBSTRATE | - |
dc.subject | MARKER | - |
dc.title | ROS activated prodrug for ALDH overexpressed cancer stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1039/d1cc05573a | - |
dc.identifier.scopusid | 2-s2.0-85121707538 | - |
dc.identifier.wosid | 000727586300001 | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.58, no.1, pp.72 - 75 | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 75 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ALDEHYDE DEHYDROGENASE ALDH | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | MARKER | - |
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