The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins
DC Field | Value | Language |
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dc.contributor.author | Park, Joori | - |
dc.contributor.author | Chang, Jeeyoon | - |
dc.contributor.author | Hwang, Hyun Jung | - |
dc.contributor.author | Jeong, Kwon | - |
dc.contributor.author | Lee, Hyuk-Joon | - |
dc.contributor.author | Ha, Hongseok | - |
dc.contributor.author | Park, Yeonkyoung | - |
dc.contributor.author | Lim, Chunghun | - |
dc.contributor.author | Woo, Jae-Sung | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2022-02-12T09:41:17Z | - |
dc.date.available | 2022-02-12T09:41:17Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-12-02 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135478 | - |
dc.description.abstract | The pioneer (or first) round of translation of newly synthesized mRNAs is largely mediated by a nuclear cap-binding complex (CBC). In a transcriptome-wide analysis of polysome-associated and CBC-bound transcripts, we identify RN7SL1, a noncoding RNA component of a signal recognition particle (SRP), as an interaction partner of the CBC. The direct CBC-SRP interaction safeguards against abnormal expression of polypeptides from a ribosome-nascent chain complex (RNC)-SRP complex until the latter is properly delivered to the endoplasmic reticulum. Failure of this surveillance causes abnormal expression of misfolded proteins at inappropriate intracellular locations, leading to a cytosolic stress response. This surveillance pathway also blocks protein synthesis through RNC-SRP misassembled on an mRNA encoding a mitochondrial protein. Thus, our results reveal a surveillance pathway in which pioneer translation ensures proper targeting of endoplasmic reticulum and mitochondrial proteins. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | SIGNAL RECOGNITION PARTICLE | - |
dc.subject | CAP-BINDING COMPLEX | - |
dc.subject | MESSENGER-RNAS | - |
dc.subject | ENDOPLASMIC-RETICULUM | - |
dc.subject | SRP INTERACTION | - |
dc.subject | QUALITY-CONTROL | - |
dc.subject | MEMBRANE | - |
dc.subject | RECEPTOR | - |
dc.subject | TRANSLOCATION | - |
dc.subject | DEGRADATION | - |
dc.title | The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Woo, Jae-Sung | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1093/nar/gkab1098 | - |
dc.identifier.scopusid | 2-s2.0-85122294945 | - |
dc.identifier.wosid | 000733312000039 | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.49, no.21, pp.12517 - 12534 | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 49 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 12517 | - |
dc.citation.endPage | 12534 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | CAP-BINDING COMPLEX | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SIGNAL RECOGNITION PARTICLE | - |
dc.subject.keywordPlus | SRP INTERACTION | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
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