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Effect of rapid fluid administration on the prognosis of septic shock patients with isolated hyperlactatemia: A prospective multicenter observational study

Authors
Lee, HeekyungChoi, Sung-HyukKim, KyuseokShin, Tae GunPark, Yoo SeokRyoo, Seung MokSuh, Gil JoonKwon, Woon YongLim, Tae HoSon, DongheeKim, Won YoungKo, Byuk Sung
Issue Date
12월-2021
Publisher
W B SAUNDERS CO-ELSEVIER INC
Keywords
Fluid resuscitation; Hyperlactatemia; Mortality; Septic shock
Citation
JOURNAL OF CRITICAL CARE, v.66, pp.154 - 159
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CRITICAL CARE
Volume
66
Start Page
154
End Page
159
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135558
DOI
10.1016/j.jcrc.2021.07.003
ISSN
0883-9441
Abstract
Background: We aimed to investigate the association between initial fluid resuscitation in septic shock patients with isolated hyperlactatemia and outcomes. Methods: This multicenter prospective study was conducted using the data from the Korean Shock Society regis -try. Patients diagnosed with isolated hyperlactatemia between October 2015 and December 2018 were included and divided into those who received 30 mL/kg of fluid within 3 or 6 h and those who did not receive. The primary outcome was in-hospital mortality; the secondary outcomes were intensive care unit (ICU) admission, length of ICU stay, mechanical ventilation, and renal replacement therapy (RRT). Results: A total of 608 patients were included in our analysis. The administration of 30 mL/kg crystalloid within 3 or 6 h was not significantly associated with in-hospital mortality in multivariable logistic regression analysis ([OR, 0.8; 95% CI, 0.52-1.23, p = 0.31], [OR, 0.96; 95% CI, 0.59-1.57, p = 0.88], respectively). The administration of 30 mL/kg crystalloid within 3-h was not significantly associated with mechanical ventilation and RRT ([OR, 1.19; 95% CI, 0.77-1.84, p = 0.44], [OR, 1.2; 95% CI, 0.7-2.04, p = 0.5], respectively). However, the administration of 30 mL/kg crystalloid within 6 h was associated with higher ICU admission and RRT ([OR, 1.57; 95% CI, 1.07-2.28, p = 0.02], [OR, 2.08; 95% CI, 1.19-3.66, p = 0.01], respectively). Conclusions: Initial fluid resuscitation of 30 mL/kg within 3 or 6 h was neither associated with an increased or decreased in-hospital mortality in septic shock patients with isolated hyperlactatemia. (c) 2021 Elsevier Inc. All rights reserved.
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