Effects of high versus low inspiratory oxygen fraction on postoperative clinical outcomes in patients undergoing surgery under general anesthesia: A systematic review and meta-analysis of randomized controlled trials
DC Field | Value | Language |
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dc.contributor.author | Lim, Choon-Hak | - |
dc.contributor.author | Han, Ju-young | - |
dc.contributor.author | Cha, Seung-ha | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Yoo, Kyung-Yeon | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.date.accessioned | 2022-02-13T04:41:03Z | - |
dc.date.available | 2022-02-13T04:41:03Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0952-8180 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135583 | - |
dc.description.abstract | Objectives: To determine whether high perioperative inspired oxygen fraction (FiO2) compared with low FiO2 has more deleterious postoperative clinical outcomes in patients undergoing non-thoracic surgery under general anesthesia. Design: Meta-analysis of randomized controlled trials. Setting: Operating room, postoperative recovery room and surgical ward. Patients: Surgical patients under general anesthesia. Intervention: High perioperative FiO2 (>= 0.8) vs. low FiO2 (<= 0.5). Measurements: The primary outcome was mortality within 30 days. Secondary outcomes were pulmonary outcomes (atelectasis, pneumonia, respiratory failure, postoperative pulmonary complications [PPCs], and postoperative oxygen parameters), intensive care unit (ICU) admissions, and length of hospital stay. A subgroup analysis was performed to explore the treatment effect by body mass index (BMI). Main results: Twenty-six trials with a total 4991 patients were studied. The mortality in the high FiO2 group did not differ from that in the low FiO2 group (risk ratio [RR] 0.91, 95% confidence interval [CI] 0.42-1.97, P = 0.810). Nor were there any significant differences between the groups in such outcomes as pneumonia (RR 1.19, 95% CI 0.74-1.92, P = 0.470), respiratory failure (RR 1.29, 95% CI 0.82-2.04, P = 0.270), PPCs (RR 1.05, 95% CI 0.69-1.59, P = 0.830), ICU admission (RR 0.94, 95% CI 0.55-1.60, P = 0.810), and length of hospital stay (mean difference [MD] 0.27 d, 95% CI -0.28-0.81, P = 0.340). The high FiO2 was associated with postoperative atelectasis more often (risk ratio 1.27, 95% CI 1.00-1.62, P = 0.050), and lower postoperative arterial partial oxygen pressure (MD -5.03 mmHg, 95% CI -7.90- -2.16, P < 0.001). In subgroup analysis of BMI >30 kg/m2, these parameters were similarly affected between the groups. Conclusions: The use of high FiO2 compared to low FiO2 did not affect the short-term mortality, although it may increase the incidence of atelectasis in adult, non-thoracic patients undergoing surgical procedures. Nor were there any significant differences in other secondary outcomes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SURGICAL SITE INFECTION | - |
dc.subject | PERIOPERATIVE SUPPLEMENTAL OXYGEN | - |
dc.subject | LONG-TERM MORTALITY | - |
dc.subject | INSPIRED OXYGEN | - |
dc.subject | 30-35-PERCENT FRACTION | - |
dc.subject | TRACHEAL EXTUBATION | - |
dc.subject | 100-PERCENT OXYGEN | - |
dc.subject | PULMONARY-FUNCTION | - |
dc.subject | ABDOMINAL-SURGERY | - |
dc.subject | WOUND-INFECTION | - |
dc.title | Effects of high versus low inspiratory oxygen fraction on postoperative clinical outcomes in patients undergoing surgery under general anesthesia: A systematic review and meta-analysis of randomized controlled trials | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Choon-Hak | - |
dc.identifier.doi | 10.1016/j.jclinane.2021.110461 | - |
dc.identifier.scopusid | 2-s2.0-85114610255 | - |
dc.identifier.wosid | 000704408200014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ANESTHESIA, v.75 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ANESTHESIA | - |
dc.citation.title | JOURNAL OF CLINICAL ANESTHESIA | - |
dc.citation.volume | 75 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordPlus | 100-PERCENT OXYGEN | - |
dc.subject.keywordPlus | 30-35-PERCENT FRACTION | - |
dc.subject.keywordPlus | ABDOMINAL-SURGERY | - |
dc.subject.keywordPlus | INSPIRED OXYGEN | - |
dc.subject.keywordPlus | LONG-TERM MORTALITY | - |
dc.subject.keywordPlus | PERIOPERATIVE SUPPLEMENTAL OXYGEN | - |
dc.subject.keywordPlus | PULMONARY-FUNCTION | - |
dc.subject.keywordPlus | SURGICAL SITE INFECTION | - |
dc.subject.keywordPlus | TRACHEAL EXTUBATION | - |
dc.subject.keywordPlus | WOUND-INFECTION | - |
dc.subject.keywordAuthor | Atelectasis | - |
dc.subject.keywordAuthor | General anesthesia | - |
dc.subject.keywordAuthor | Inspiratory oxygen fraction | - |
dc.subject.keywordAuthor | Pneumonia | - |
dc.subject.keywordAuthor | Postoperative outcome | - |
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