Risk of Diabetes in Patients with Long-Standing Graves' Disease: A Longitudinal Study
DC Field | Value | Language |
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dc.contributor.author | Song, Eyun | - |
dc.contributor.author | Koo, Min Ji | - |
dc.contributor.author | Noh, Eunjin | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Park, Min Jeong | - |
dc.contributor.author | Kim, Jung A. | - |
dc.contributor.author | Roh, Eun | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Cho, Geum Joon | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.date.accessioned | 2022-02-13T16:40:19Z | - |
dc.date.available | 2022-02-13T16:40:19Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135640 | - |
dc.description.abstract | Background: The detrimental effects of excessive thyroid hormone on glucose metabolism have been widely investigated. However, the risk of diabetes in patients with long-standing hyperthyroidism, especially according to treatment modality, remains uncertain, with few longitudinal studies. Methods: The risk of diabetes in patients with Graves' disease treated with antithyroid drugs (ATDs) for longer than the conventional duration (>= 2 years) was compared with that in age-and sex-matched controls. The risk was further compared according to subsequent treatment modalities after a 24-month course of ATD: continuation of ATD (ATD group) vs. radioactive iodine ablation (RIA) group. Results: A total of 4,593 patients were included. Diabetes was diagnosed in 751 (16.3%) patients over a follow-up of 7.3 years. The hazard ratio (HR) for diabetes, after adjusting for various known risk factors, was 1.18 (95% confidence interval [CI], 1.10 to 1.28) in patients with hyperthyroidism. Among the treatment modality groups, the RIA group (n=102) had a higher risk of diabetes than the ATD group (n=4,491) with HR of 1.56 (95% CI, 1.01 to 2.42). Further, the risk of diabetes increased with an increase in the ATD treatment duration (P for trend=0.019). Conclusion: The risk of diabetes was significantly higher in patients with long-standing Graves' disease than in the general population, especially in patients who underwent RIA and prolonged ATD treatment. Special attention to hyperglycemia during follow-up along with effective control of hyperthyroidism may be necessary to reduce the risk of diabetes in these patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.subject | THYROID-DYSFUNCTION | - |
dc.subject | GLUCOSE-TOLERANCE | - |
dc.subject | ANTITHYROID DRUGS | - |
dc.subject | MANAGEMENT | - |
dc.subject | HYPERTHYROIDISM | - |
dc.subject | METABOLISM | - |
dc.subject | INSULIN | - |
dc.subject | SECRETION | - |
dc.subject | FREQUENCY | - |
dc.subject | DIAGNOSIS | - |
dc.title | Risk of Diabetes in Patients with Long-Standing Graves' Disease: A Longitudinal Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.identifier.doi | 10.3803/EnM.2021.1251 | - |
dc.identifier.scopusid | 2-s2.0-85123411031 | - |
dc.identifier.wosid | 000739086400013 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.36, no.6, pp.1277 - 1286 | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 36 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1277 | - |
dc.citation.endPage | 1286 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002790029 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | THYROID-DYSFUNCTION | - |
dc.subject.keywordPlus | GLUCOSE-TOLERANCE | - |
dc.subject.keywordPlus | ANTITHYROID DRUGS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | HYPERTHYROIDISM | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | FREQUENCY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | Hyperthyroidism | - |
dc.subject.keywordAuthor | Graves disease | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Antithyroid agents | - |
dc.subject.keywordAuthor | Radioiodine ablation | - |
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