Development of a Proton-Frequency-Transparent Birdcage Radiofrequency Coil for In Vivo C-13 MRS/MRSI Study in a 3.0 T MRI System
- Authors
- Yoon, Jun-Sik; Kim, Jong-Min; Chung, Han-Jae; Jeong, You-Jin; Jeong, Gwang-Woo; Park, Ilwoo; Kim, Gwang-Won; Oh, Chang-Hyun
- Issue Date
- 12월-2021
- Publisher
- MDPI
- Keywords
- Carbon-13; birdcage RF coil; free induction decay chemical shift imaging; hyperpolarized magnetic resonance imaging; magnetic resonance spectroscopic imaging; slab dynamic MRS
- Citation
- APPLIED SCIENCES-BASEL, v.11, no.23
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED SCIENCES-BASEL
- Volume
- 11
- Number
- 23
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135643
- DOI
- 10.3390/app112311445
- ISSN
- 2076-3417
- Abstract
- A proton-frequency-transparent (PFT) birdcage RF coil that contains carbon-proton switching circuits (CPSCs) is presented to acquire C-13 MR signals, which, in turn, enable H-1 imaging with existing H-1 RF coils without being affected by a transparent C-13 birdcage RF coil. CPSCs were installed in the PFT C-13 birdcage RF coil to cut the RF coil circuits during H-1 MR imaging. Finite-difference time-domain (FDTD) electromagnetic (EM) simulations were performed to verify the performance of the proposed CPSCs. The performance of the PFT C-13 birdcage RF coil with CPSCs was verified via phantom and in vivo MR studies. In the phantom MR studies, H-1 MR images and C-13 MR spectra were acquired and compared with each other using the C-13 birdcage RF coil with and without the CPSCs. For the in vivo MR studies, hyperpolarized C-13 cardiac MRS and MRSI of swine were performed. The proposed PFT C-13 birdcage RF coil with CPSCs led to a percent image uniformity (PIU) reduction of 1.53% in the proton MR images when compared with the case without it. FDTD EM simulations revealed PIU reduction of 0.06% under the same conditions as the phantom MR studies. Furthermore, an SNR reduction of 5.5% was observed at C-13 MR spectra of corn-oil phantom using the PFT C-13 birdcage RF coil with CPSCs compared with that of the C-13 birdcage RF coil without CPSCs. Utilizing the PFT C-13 birdcage RF coil, C-13-enriched compounds were successfully acquired via in vivo hyperpolarized C-13 MRS/MRSI experiments. In conclusion, the applicability and utility of the proposed 16-leg low-pass PFT C-13 birdcage RF coil with CPSCs were verified via H-1 MR imaging and hyperpolarized C-13 MRS/MRSI studies using a 3.0 T MRI system.
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