Inhibition of Human Osteoclast Differentiation by Kynurenine through the Aryl-Hydrocarbon Receptor Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, So-Yeon | - |
dc.contributor.author | Oh, Younseo | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Ji, Jong-Dae | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.date.accessioned | 2022-02-13T17:40:35Z | - |
dc.date.available | 2022-02-13T17:40:35Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135646 | - |
dc.description.abstract | Aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor and regulates differentiation and function of various immune cells such as dendritic cells, Th17, and regulatory T cells. In recent studies, it was reported that AhR is involved in bone remodeling through regulating both osteoblasts and osteoclasts. However, the roles and mechanisms of AhR activation in human osteoclasts remain unknown. Here we show that AhR is involved in human osteoclast differentiation. We found that AhR expressed highly in the early stage of osteoclastogenesis and decreased in mature osteoclasts. Kynurenine (Kyn), formylindolo[3,4-b] carbazole (FICZ), and benzopyrene (BaP), which are AhR agonists, inhibited osteoclast formation and Kyn suppressed osteoclast differentiation at an early stage. Furthermore, blockade of AhR signaling through CH223191, an AhR antagonist, and knockdown of AhR expression reversed Kyn-induced inhibition of osteoclast differentiation. Overall, our study is the first report that AhR negatively regulates human osteoclast differentiation and suggests that AhR could be good therapeutic molecule to prevent bone destruction in chronic inflammatory diseases such as rheumatoid arthritis (RA). | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | C-MYC | - |
dc.subject | INDUCTION | - |
dc.title | Inhibition of Human Osteoclast Differentiation by Kynurenine through the Aryl-Hydrocarbon Receptor Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Jong-Dae | - |
dc.identifier.doi | 10.3390/cells10123498 | - |
dc.identifier.scopusid | 2-s2.0-85120795988 | - |
dc.identifier.wosid | 000736277200001 | - |
dc.identifier.bibliographicCitation | CELLS, v.10, no.12 | - |
dc.relation.isPartOf | CELLS | - |
dc.citation.title | CELLS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | aryl-hydrocarbon receptor | - |
dc.subject.keywordAuthor | bone remodeling | - |
dc.subject.keywordAuthor | kynurenine | - |
dc.subject.keywordAuthor | osteoclast | - |
dc.subject.keywordAuthor | osteoclastogenesis | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.