Analysis of Microvasculature in Nonhuman Primate Macula With Acute Elevated Intraocular Pressure Using Optical Coherence Tomography Angiography
DC Field | Value | Language |
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dc.contributor.author | Choi, Mihyun | - |
dc.contributor.author | Kim, Seong-Woo | - |
dc.contributor.author | Vu, Thi Que Anh | - |
dc.contributor.author | Kim, Young-Jin | - |
dc.contributor.author | Jung, Hachul | - |
dc.contributor.author | Shin, Donggwan | - |
dc.contributor.author | Eom, Heejong | - |
dc.contributor.author | Kim, Young Ho | - |
dc.contributor.author | Yun, Cheolmin | - |
dc.contributor.author | Kim, Yong Yeon | - |
dc.date.accessioned | 2022-02-13T22:40:29Z | - |
dc.date.available | 2022-02-13T22:40:29Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0146-0404 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135671 | - |
dc.description.abstract | PURPOSE. To investigate responses of macular capillary vessel area density (VAD) of superficial and deep retinal vascular plexuses to elevations in intraocular pressure (IOP) in cynomolgus macaque monkeys using optical coherence tomography angiography (OCTA). METHODS. In five general anesthetized male cynomolgus monkeys, the IOP was increased incrementally by 10 mmHg from baseline (10 mmHg) to 70 mmHg and then decreased back to 10 mmHg (recovery state). Structural OCT (30 degrees x 30 degrees) and OCTA (20 degrees x 15 degrees) centered on the macula were obtained at each IOP and 3, 15, and 30 minutes after recovery. En face images of the superficial vascular complex (SVC) and deep vascular complex (DVC) were extracted, and VAD (%) compared with that at baseline was calculated. RESULTS. The VADs in the SVC and DVC at baseline and at 30 mmHg IOP were 34.96%, 34.15%, 35.38%, and 30.12%, respectively. The VAD plateaued until 30 mmHg; however, the VAD was affected more in the DVC than in the SVC (P = 0.008) at 30 mmHg. It showed a significant reduction at 40 mmHg (16.52% SVC, P = 0.006; 18.59% DVC, P = 0.012). In the recovery state, the SVC showed full retention of baseline VAD, but the DVC maintained VAD approximately 70% of that at baseline. Structural OCT showed hyperreflectivity in the nuclear layer, retinal swelling, and an undifferentiated ellipsoid zone from 50 mmHg. CONCLUSIONS. Despite physiological autoregulation, perifoveal microcirculation was affected at high IOP >= 40 mmHg, especially in the DVC, which explains the pathological mechanism of macular vulnerability in ischemic diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | - |
dc.subject | OCULAR PERFUSION-PRESSURE | - |
dc.subject | RETINAL ARTERY-OCCLUSION | - |
dc.subject | FOVEAL AVASCULAR ZONE | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | RATS | - |
dc.subject | VASCULATURE | - |
dc.subject | THICKNESS | - |
dc.subject | DECREASE | - |
dc.subject | ANATOMY | - |
dc.subject | MONKEYS | - |
dc.title | Analysis of Microvasculature in Nonhuman Primate Macula With Acute Elevated Intraocular Pressure Using Optical Coherence Tomography Angiography | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seong-Woo | - |
dc.identifier.doi | 10.1167/iovs.62.15.18 | - |
dc.identifier.scopusid | 2-s2.0-85122374276 | - |
dc.identifier.wosid | 000735583300001 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v.62, no.15 | - |
dc.relation.isPartOf | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | - |
dc.citation.title | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | - |
dc.citation.volume | 62 | - |
dc.citation.number | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | ANATOMY | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | DECREASE | - |
dc.subject.keywordPlus | FOVEAL AVASCULAR ZONE | - |
dc.subject.keywordPlus | MONKEYS | - |
dc.subject.keywordPlus | OCULAR PERFUSION-PRESSURE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | RETINAL ARTERY-OCCLUSION | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | VASCULATURE | - |
dc.subject.keywordAuthor | angiography | - |
dc.subject.keywordAuthor | intraocular pressure | - |
dc.subject.keywordAuthor | microcirculation | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
dc.subject.keywordAuthor | retina | - |
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