IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes (vol 14, 23, 2020)

Abstract

In the original article, there was a mistake in Figure 3 as published. It was due to an inadvertent mistake in the quantification process. The new quantification indicates that there is no statistical difference in the NMDA/AMPA ratio between WT and IRSp53-KO mice; previous Figure 3C indicated a decrease in the mutant mice. The correct Figure 3 and legend appears below. To reflect this change a correction has also been made to the Results, Emx1-Cre; Irsp53fl/fl and Viaat-Cre; Irsp53 Mice Show Distinct Changes in Synaptic Transmission and Intrinsic Excitability in mPFC Pyramidal Neurons, Second paragraph: “When evoked synaptic transmission was measured, the ratio of NMDAR-mediated EPSCs and AMPA receptor (AMPAR)-mediated EPSCs was not altered in Emx1-Cre; Irsp53fl/fl layer V pyramidal neurons (Figure 3C). These results collectively suggest that Irsp53 deletion in glutamatergic neurons leads to reduced spontaneous excitatory but not inhibitory synaptic transmission, increased ratio of evoked EPSCs/IPSCs, and increased neuronal excitability without affecting evoked NMDAR-EPSC/AMPAR-EPSC ratio in layer V mPFC neurons.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. © 2021, Kim, Noh, Kim, Yang, Kim and Kim.