Hand-Held Raman Spectrometer-Based Dual Detection of Creatinine and Cortisol in Human Sweat Using Silver Nanoflakes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun Soo | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Lee, Jaehun | - |
dc.contributor.author | Lee, Taeha | - |
dc.contributor.author | Yun, Jongsu | - |
dc.contributor.author | Lee, Gyudo | - |
dc.contributor.author | Hong, Yoochan | - |
dc.date.accessioned | 2022-02-14T06:40:43Z | - |
dc.date.available | 2022-02-14T06:40:43Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-11-16 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135711 | - |
dc.description.abstract | The conventional tissue biopsy method yields isolated snapshots of a narrow region. Therefore, it cannot facilitate comprehensive disease characterization and monitoring. Recently, the detection of tumor-derived components in body fluids-a practice known as liquid biopsy-has attracted increased attention from the biochemical research and clinical application viewpoints. In this vein, surface-enhanced Raman scattering (SERS) has been identified as one of the most powerful liquid-biopsy analysis techniques, owing to its high sensitivity and specificity. Moreover, it affords high-capacity spectral multiplexing for simultaneous target detection and a unique ability to obtain intrinsic biomolecule-fingerprint spectra. This paper presents the fabrication of silver nanosnowflakes (SNSFs) using the polyol method and their subsequent dropping onto a hydrophobic filter paper. The SERS substrate, which comprises the SNSFs and hydrophobic filter paper, facilitates the simultaneous detection of creatinine and cortisol in human sweat using a hand-held Raman spectrometer. The proposed SERS system affords Raman spectrometry to be performed on small sample volumes (2 mu L) to identify the normal and at-risk creatinine and cortisol groups. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | SERS | - |
dc.subject | SENSITIVITY | - |
dc.subject | DEPOSITION | - |
dc.title | Hand-Held Raman Spectrometer-Based Dual Detection of Creatinine and Cortisol in Human Sweat Using Silver Nanoflakes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Gyudo | - |
dc.identifier.doi | 10.1021/acs.analchem.1c02496 | - |
dc.identifier.scopusid | 2-s2.0-85119279481 | - |
dc.identifier.wosid | 000721110000013 | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.93, no.45, pp.14996 - 15004 | - |
dc.relation.isPartOf | ANALYTICAL CHEMISTRY | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 93 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 14996 | - |
dc.citation.endPage | 15004 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | DEPOSITION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | SERS | - |
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