Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors
DC Field | Value | Language |
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dc.contributor.author | Kim, Yujin | - |
dc.contributor.author | Ma, Chao | - |
dc.contributor.author | Park, Seonghu | - |
dc.contributor.author | Shin-, Yujin | - |
dc.contributor.author | Lee, Taeyun | - |
dc.contributor.author | Paek, Jiwon | - |
dc.contributor.author | Kim, Kyong Hoon | - |
dc.contributor.author | Jang, Geonhee | - |
dc.contributor.author | Cho, Haelim | - |
dc.contributor.author | Son, Seyoung | - |
dc.contributor.author | Son, Sang-Hyun | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.date.accessioned | 2022-02-14T10:41:01Z | - |
dc.date.available | 2022-02-14T10:41:01Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-11-15 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135733 | - |
dc.description.abstract | Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-related diseases, no small molecule that inhibits IL-33 has been reported. Based on the structure-activity relationship and in vitro 2D NMR studies employing N-15-labeled IL-33, we identified that the oxazolo[4,5-c]-quinolinone analog 7 c binds to the interface region of IL-33 and IL-33 receptor (ST2), an orphan receptor of the IL-1 receptor family. Compound 7 c effectively inhibited the production of IL-6 in human mast cells in a dose-dependent manner. Compound 7 c is the first low molecular weight IL-33 inhibitor and may be used as a prototype molecule for structural optimization and investigation of the IL-33/ST2 signaling pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | RECEPTOR ACCESSORY PROTEIN | - |
dc.subject | INNATE LYMPHOID-CELLS | - |
dc.subject | ALLERGIC INFLAMMATION | - |
dc.subject | IL-33 | - |
dc.subject | CYTOKINE | - |
dc.subject | ST2 | - |
dc.subject | TAUTOMERISM | - |
dc.subject | INSIGHTS | - |
dc.subject | ALKYL | - |
dc.title | Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.1002/asia.202100896 | - |
dc.identifier.scopusid | 2-s2.0-85119086324 | - |
dc.identifier.wosid | 000700474800001 | - |
dc.identifier.bibliographicCitation | CHEMISTRY-AN ASIAN JOURNAL, v.16, no.22, pp.3702 - 3712 | - |
dc.relation.isPartOf | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.title | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.volume | 16 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 3702 | - |
dc.citation.endPage | 3712 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ALKYL | - |
dc.subject.keywordPlus | ALLERGIC INFLAMMATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | IL-33 | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | RECEPTOR ACCESSORY PROTEIN | - |
dc.subject.keywordPlus | ST2 | - |
dc.subject.keywordPlus | TAUTOMERISM | - |
dc.subject.keywordAuthor | Allergy | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Inhibitors | - |
dc.subject.keywordAuthor | Interleukin-33 | - |
dc.subject.keywordAuthor | Oxazoloquinoline | - |
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