Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
DC Field | Value | Language |
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dc.contributor.author | Lee, Yong-Deok | - |
dc.contributor.author | Shin, Hyeon Jeong | - |
dc.contributor.author | Yoo, Jounghyun | - |
dc.contributor.author | Kim, Gayoung | - |
dc.contributor.author | Kang, Min-Kyoung | - |
dc.contributor.author | Lee, Jae Jun | - |
dc.contributor.author | Bang, Joona | - |
dc.contributor.author | Yang, Jin-Kyoung | - |
dc.contributor.author | Kim, Sehoon | - |
dc.date.accessioned | 2022-02-14T13:40:24Z | - |
dc.date.available | 2022-02-14T13:40:24Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-11-10 | - |
dc.identifier.issn | 2196-5404 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135745 | - |
dc.description.abstract | Indocyanine green (ICG) is a clinically approved dye that has shown great promise as a phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it has certain limitations, such as poor photostability and non-specific binding to serum proteins, subjected to rapid clearance and decreased theranostic efficacy in vivo. This study reports stable and biocompatible nanoparticles of ICG (ICG-Fe NPs) where ICG is electrostatically complexed with an endogenously abundant metal ion (Fe3+) and subsequently nanoformulated with a clinically approved polymer surfactant, Pluronic F127. Under near-infrared laser irradiation, ICG-Fe NPs were found to be more effective for photothermal temperature elevation than free ICG molecules owing to the improved photostability. In addition, ICG-Fe NPs showed the markedly enhanced tumor targeting and visualization with photoacoustic/fluorescent signaling upon intravenous injection, attributed to the stable metal complexation that prevents ICG-Fe NPs from releasing free ICG before tumor targeting. Under dual-modal imaging guidance, ICG-Fe NPs could successfully potentiate photothermal therapy of cancer by applying near-infrared laser irradiation, holding potential as a promising nanomedicine composed of all biocompatible ingredients for clinically relevant phototheranostics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | INDOCYANINE-GREEN | - |
dc.subject | PHOTOTHERMAL THERAPY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | SENSORS | - |
dc.subject | BIODISTRIBUTION | - |
dc.subject | DERIVATIVES | - |
dc.subject | FE3+ | - |
dc.title | Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics | - |
dc.title.alternative | Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, Joona | - |
dc.identifier.doi | 10.1186/s40580-021-00286-3 | - |
dc.identifier.scopusid | 2-s2.0-85118779899 | - |
dc.identifier.wosid | 000716927300001 | - |
dc.identifier.bibliographicCitation | NANO CONVERGENCE, v.8, no.1, pp.1 - 11 | - |
dc.relation.isPartOf | NANO CONVERGENCE | - |
dc.citation.title | NANO CONVERGENCE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002811117 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | INDOCYANINE-GREEN | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | FE3+ | - |
dc.subject.keywordAuthor | Indocyanine green | - |
dc.subject.keywordAuthor | Metal complex | - |
dc.subject.keywordAuthor | Dual-modal imaging | - |
dc.subject.keywordAuthor | Photothermal therapy | - |
dc.subject.keywordAuthor | Theranostics | - |
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