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Brain amyloid accumulation possibly exacerbates concurrent mild cognitive impairment with subthreshold depression in older adults: A 1-year follow-up study

Authors
Youn, H.Hyung, W.S.W.Kim, J.Lee, E.S.Eo, J.S.Han, C.E.Han, C.Kim, S.H.Jeong, H.-G.
Issue Date
1-12월-2021
Publisher
Elsevier B.V.
Keywords
Alzheimer disease; Amyloid; Cognitive dysfunction; Late‐life depression; Memory; Positron emission tomography
Citation
Journal of Affective Disorders, v.295, pp.93 - 100
Indexed
SCIE
SSCI
SCOPUS
Journal Title
Journal of Affective Disorders
Volume
295
Start Page
93
End Page
100
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135810
DOI
10.1016/j.jad.2021.08.017
ISSN
0165-0327
Abstract
Background: This study aimed to investigate the 1-year changes in neuropsychological test results in older adults with concomitant late-life depression (LLD) and mild cognitive impairment (MCI) according to the presence or absence of brain amyloidopathy. Methods: All subjects underwent 18F‐florbetaben‐positron emission tomography and a standardized neuropsychological battery. The subjects were divided based on brain amyloidopathy and severity of depressive symptoms into the following groups: LLD-MCI-A(+), subthreshold depression (STD)-MCI-A(+), major depressive disorder (MDD)-MCI-A(+), LLD-MCI-A(-), STD-MCI-A(-), and MDD-MCI-A(-). After one year, follow-up neurocognitive tests were conducted. Fifty-nine participants completed both the baseline and 1-year follow-up neurocognitive tests. Results: In the LLD-MCI-A(+) group, the word list recall and word list recognition scores decreased during the follow-up period. The STD-MCI-A(+) group also showed a significant decrease in word list recall score and the score/Z-score of word list recognition. On the other hand, the word list recall Z-score improved at the 1-year follow-up in the LLD-MCI-A(-) group. In particular, the MDD-MCI-A(-) group showed significant increases in word list memory score/Z-score and word list recall Z-score during the follow-up period. Limitations: Considering that AD progresses slowly, a longer follow-up period may be required. Conclusions: Our findings showed differences in the extent of change of neuropsychological test results depending on the severity of depressive symptoms and presence or absence of brain amyloidopathy. Our results suggest that clinicians might explore the underlying neuropathology when assessing older adults with concomitant depression and cognitive impairment, even if the symptoms of depression are not severe. © 2021
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