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Body fat percentage and availability of oral food intake: Prognostic factors and implications for nutrition in amyotrophic lateral sclerosis

Authors
Park, J.-W.Kim, M.Baek, S.-H.Sung, J.H.Yu, J.-G.Kim, B.-J.
Issue Date
11월-2021
Publisher
MDPI
Keywords
Amyotrophic lateral sclerosis; Body fat percentage; Oral food intake; Survival
Citation
Nutrients, v.13, no.11
Indexed
SCIE
SCOPUS
Journal Title
Nutrients
Volume
13
Number
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135817
DOI
10.3390/nu13113704
ISSN
2072-6643
Abstract
Adequate nutritional support and high body mass index (BMI) are good prognostic factors for disease progression and survival in amyotrophic lateral sclerosis (ALS). However, whether the composition of body weight, such as body fat percentage, has an independent effect on ALS prognosis remains unclear. The clinical data of 53 ALS patients were collected by medical record review. The data included: disease onset, sex, age, time of diagnosis, survival duration, presence of percutaneous endoscopic gastrostomy (PEG), nasogastric tube, tracheostomy, and availability of oral intake throughout the course of the disease, and interval measurement values of body mass by bioelectrical impedance analysis (BIA). The interval change (∆) of the BIA parameters was calculated by subtracting the follow-up values from the baseline values. Change in body fat percentage/interval between BIA measurements (months) (hazard ratio [HR] = 0.374, p = 0.0247), and availability of oral food intake (HR = 0.167, p = 0.02), were statistically significant for survival duration in multivariate hazard proportional regression analysis. Survival analysis and Kaplan– Meier curves showed similar results. Higher average monthly change in body fat percentage and availability of oral food intake are prognostic factors in ALS survival. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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