Predictors of Favorable Angiographic Outcomes After Drug-Coated Balloon Use for de novo Small Vessel Coronary Disease (DCB-ONLY)
- Authors
- Kang, Woong Chol; Park, Sang Min; Jang, Albert Youngwoo; Oh, Pyung Chun; Shin, Eun-Seok; Yu, Cheol Woong; Oh, Seung-Jin; Kim, Yong Hoon; Won, Hoyoun; Lee, Sang-Rok; Lee, Sang Yeub; Hong, Young Joon; Lee, Sung Yun; Kim, Byung Ok; Kim, Sang-Wook
- Issue Date
- 11월-2021
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- drug-coated balloon; late luminal loss; small vessel coronary disease; target lesion failure
- Citation
- ANGIOLOGY, v.72, no.10, pp.986 - 993
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANGIOLOGY
- Volume
- 72
- Number
- 10
- Start Page
- 986
- End Page
- 993
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135832
- DOI
- 10.1177/00033197211015534
- ISSN
- 0003-3197
- Abstract
- We evaluated the angiographic parameter and clinical outcomes of drug-coated balloon (DCB) to assess the optimal angiographic criteria in de novo small vessel disease (SVD). Patients (n = 424, mean age: 64.4 +/- 11.2 years, men: 69.8%) at 20 sites in Korea were prospectively enrolled. The primary end point was late luminal loss (LLL) at 9-month follow-up angiography. Secondary end points included restenosis rates, target lesion failure (TLF), and DCB-related thrombosis during the 12-month follow-up period. We included 403 patients for analysis excluding 21 patients who required bailout stenting. Baseline mean reference vessel .diameter was 2.52 +/- 0.39 mm and mean minimal luminal diameter (MLD) was 0.71 +/- 0.40 mm. The mean MLD was 1.54 +/- 0.37 mm after DCB. Late luminal loss was -0.01 +/- 0.43 mm and restenosis was noted in 26 patients (12.2%). Minimal luminal diameter >1.6 mm and %diameter stenosis (DS) <45% after DCB was associated maintenance of MLD without LLL at 9-months. Multivariate analysis demonstrated that %DS at baseline and post-MLD was associated with the restenosis. During 12-month follow-up, TLF was 2.6% including 1 cardiac death, 1 myocardial infarction, and 10 ischemia-driven target lesion revascularizations. Drug-coated balloon showed a low restenosis and lower LLL despite high in-segment DS. Post-MLD and % DS may be helpful to get optimal results in de novo SVD after DCB.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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