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Phytochemicals for the treatment of COVID-19

Authors
Espano, EricaKim, JiyeonLee, KihoKim, Jeong-Ki
Issue Date
11월-2021
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Keywords
COVID-19; SARS-CoV-2; alkaloids; antivirals; coronaviruses; flavonoids; natural products; phytochemicals
Citation
JOURNAL OF MICROBIOLOGY, v.59, no.11, pp.959 - 977
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MICROBIOLOGY
Volume
59
Number
11
Start Page
959
End Page
977
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135844
DOI
10.1007/s12275-021-1467-z
ISSN
1225-8873
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.
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