beta 2-adrenergic receptor expression and the effects of norepinephrine and propranolol on various head and neck cancer subtypes
DC Field | Value | Language |
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dc.contributor.author | Kwon, Soon Young | - |
dc.contributor.author | Chun, Kyung Ju | - |
dc.contributor.author | Kil, Hong Kwon | - |
dc.contributor.author | Jung, Narae | - |
dc.contributor.author | Shin, Hyun-Ah | - |
dc.contributor.author | Jang, Jeon Yeob | - |
dc.contributor.author | Choi, Hyo Geun | - |
dc.contributor.author | Oh, Kyoung-Ho | - |
dc.contributor.author | Kim, Min-Su | - |
dc.date.accessioned | 2022-02-15T13:41:55Z | - |
dc.date.available | 2022-02-15T13:41:55Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135867 | - |
dc.description.abstract | The present study aimed to investigate expression of beta 2-adrenergic receptor (AR), the effect of the stress-related neurotransmitter norepinephrine (NE) on cell viability, proliferation and the therapeutic effect of propranolol, which is a typical beta-blocker in various type of head and neck cancers for the first time. The beta 2-AR expression was investigated using immunohistochemistry and an immunoreactive scoring (IRS) system in 57 different head and neck cancer specimens, and reverse transcriptase-polymerase chain reaction and western blotting in four head and neck cancer cell lines (HNCCLs). Cell viability and proliferation assays were performed using 0, 1, 5 and 10 mu M of NE and 1 mu M of propranolol in four HNCCLs. The expression of beta 2-AR was positive in the majority of head and neck cancer tissues (55/57, 96.5%); however, it was significantly higher in oral cavity cancer than in pharyngeal cancer (median IRS: 9 vs. 3; P<0.001). All HNCCLs exhibited beta 2-AR expression, with a higher expression level detected in the oral cavity cancer cell line than in the others. NE stimulated viability (oral cavity, 206%; larynx, 156%; pharynx, 130%; nasal cavity, 137%; 10 mu M NE) and proliferation (124, 176, 131 and 127%, respectively) in a dose-dependent manner in all HNCCLs. Conversely, propranolol attenuated such viability (55, 42, 18 and 22%, respectively) and proliferation (22, 40, 61 and 48%, respectively). In conclusion, the viability and proliferation of various head and neck cancers may be directly stimulated by stress and this may be attenuated by beta-blockers. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | BETA-BLOCKERS | - |
dc.subject | VEGF-C | - |
dc.subject | RECURRENCE | - |
dc.title | beta 2-adrenergic receptor expression and the effects of norepinephrine and propranolol on various head and neck cancer subtypes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Kyoung-Ho | - |
dc.identifier.doi | 10.3892/ol.2021.13065 | - |
dc.identifier.scopusid | 2-s2.0-85115981382 | - |
dc.identifier.wosid | 000700872300001 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, v.22, no.5 | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.citation.title | ONCOLOGY LETTERS | - |
dc.citation.volume | 22 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BETA-BLOCKERS | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | VEGF-C | - |
dc.subject.keywordAuthor | adrenergic beta-antagonists | - |
dc.subject.keywordAuthor | adrenergic receptor | - |
dc.subject.keywordAuthor | head and neck neoplasms | - |
dc.subject.keywordAuthor | norepinephrine | - |
dc.subject.keywordAuthor | stress | - |
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