Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
- Authors
- Bae, Seongman; Kim, Ji Yeun; Lim, So Yun; Park, Heedo; Cha, Hye Hee; Kwon, Ji-Soo; Suh, Mi Hyun; Lee, Hyun Jung; Lim, Joon Seo; Jung, Jiwon; Kim, Min Jae; Chong, Yong Pil; Lee, Sang-Oh; Choi, Sang-Ho; Kim, Yang Soo; Lee, Ho Young; Lee, Sohyun; Park, Man-Seong; Kim, Sung-Han
- Issue Date
- 11월-2021
- Publisher
- MDPI
- Keywords
- SARS-CoV-2; presymptomatic; subgenomic RNA; viable culture; viral shedding
- Citation
- VIRUSES-BASEL, v.13, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- VIRUSES-BASEL
- Volume
- 13
- Number
- 11
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135936
- DOI
- 10.3390/v13112133
- ISSN
- 1999-4915
- Abstract
- We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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