Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Truncated Milk Fat Globule-EGF-like Factor 8 Ameliorates Liver Fibrosis via Inhibition of Integrin-TGF beta Receptor Interaction

Authors
An, Geun HoLee, JaehunJin, XiongChung, JinwooKim, Joon-ChulPark, Jung-HyuckKim, MinkyungHan, ChoongseongKim, Jong-HoonWoo, Dong-Hun
Issue Date
11월-2021
Publisher
MDPI
Keywords
TGF-beta; integrin; liver disease; liver fibrosis; protein therapy
Citation
BIOMEDICINES, v.9, no.11
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICINES
Volume
9
Number
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135942
DOI
10.3390/biomedicines9111529
ISSN
2227-9059
Abstract
Milk fat globule-EGF factor 8 (MFG-E8) protein is known as an immunomodulator in various diseases, and we previously demonstrated the anti-fibrotic role of MFG-E8 in liver disease. Here, we present a truncated form of MFG-E8 that provides an advanced therapeutic benefit in treating liver fibrosis. The enhanced therapeutic potential of the modified MFG-E8 was demonstrated in various liver fibrosis animal models, and the efficacy was further confirmed in human hepatic stellate cells and a liver spheroid model. In the subsequent analysis, we found that the modified MFG-E8 more efficiently suppressed transforming growth factor beta (TGF-beta) signaling than the original form of MFG-E8, and it deactivated the proliferation of hepatic stellate cells in the liver disease environment through interfering with the interactions between integrins (alpha v beta 3 & alpha v beta 5) and TGF-beta RI. Furthermore, the protein preferentially delivered in the liver after administration, and the safety profiles of the protein were demonstrated in male and female rat models. Therefore, in conclusion, this modified MFG-E8 provides a promising new therapeutic strategy for treating fibrotic diseases.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE