Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyong Hoon | - |
dc.contributor.author | Choi, Aryeong | - |
dc.contributor.author | Kim, Sang Hoon | - |
dc.contributor.author | Song, Heonju | - |
dc.contributor.author | Jin, Seohoon | - |
dc.contributor.author | Kim, Kyungim | - |
dc.contributor.author | Jang, Jaebong | - |
dc.contributor.author | Choi, Hanbyeul | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.date.accessioned | 2022-02-16T04:42:38Z | - |
dc.date.available | 2022-02-16T04:42:38Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135944 | - |
dc.description.abstract | Memory T (T-M) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how T-M cells receive these signals, we infected mice with lymphocytic choriomeningitis virus (LCMV) and examined the expression sites of neural cadherin (N-cadherin) by immunofluorescence microscopy. We found that N-cadherin was expressed in the surroundings of the white pulps of the spleen and medulla of lymph nodes (LNs). Moreover, T-M cells expressing high levels of killer cell lectin-like receptor G1 (KLRG1), a ligand of N-cadherin, were co-localized with N-cadherin(+) cells in the spleen but not in LNs. We then blocked N-cadherin in vivo to investigate whether it regulates the formation or function of T-M cells. The numbers of CD127(hi)CD62L(hi) T-M cells in the spleen of memory P14 chimeric mice declined when N-cadherin was blocked during the contraction phase, without functional impairment of these cells. In addition, when CD127(lo)KLRG1(hi) T-M cells were adoptively transferred into anti- N-cadherin- treated mice compared with control mice, the number of these cells was reduced in the bone marrow and LNs, with-out functional loss. Taken together, our results suggest that N-cadherin participates in the development of CD127(hi)CD62L(hi) T-M cells and homing of CD127(lo)KLRG1(hi) T-M cells to lymphoid organs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | HEMATOPOIETIC-STEM-CELL | - |
dc.subject | N-CADHERIN | - |
dc.subject | EFFECTOR | - |
dc.subject | EXPRESSION | - |
dc.subject | ADHESION | - |
dc.subject | NICHE | - |
dc.subject | NAIVE | - |
dc.subject | HOMEOSTASIS | - |
dc.subject | STRATEGIES | - |
dc.subject | REGULATORS | - |
dc.title | Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jin, Seohoon | - |
dc.contributor.affiliatedAuthor | Kim, Kyungim | - |
dc.contributor.affiliatedAuthor | Jang, Jaebong | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.14348/molcells.2021.0137 | - |
dc.identifier.scopusid | 2-s2.0-85122168791 | - |
dc.identifier.wosid | 000723267900003 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.44, no.11, pp.795 - 804 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 795 | - |
dc.citation.endPage | 804 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002781698 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HEMATOPOIETIC-STEM-CELL | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | N-CADHERIN | - |
dc.subject.keywordPlus | NAIVE | - |
dc.subject.keywordPlus | NICHE | - |
dc.subject.keywordPlus | REGULATORS | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordAuthor | homeostasis | - |
dc.subject.keywordAuthor | homing | - |
dc.subject.keywordAuthor | memory CD8 T cells | - |
dc.subject.keywordAuthor | neural cadherin | - |
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