Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hae Woong | - |
dc.contributor.author | Naskar, Manisha | - |
dc.contributor.author | Seo, Ho Kyung | - |
dc.contributor.author | Lee, Hye Won | - |
dc.date.accessioned | 2022-02-16T06:42:02Z | - |
dc.date.available | 2022-02-16T06:42:02Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135951 | - |
dc.description.abstract | Urothelial bladder cancer (UBC) is one of the most prevalent and aggressive malignancies. Recent evidence indicates that the tumor microenvironment (TME), including a variety of immune cells, is a critical modulator of tumor initiation, progression, evolution, and treatment resistance. Mast cells (MCs) in UBC are possibly involved in tumor angiogenesis, tissue remodeling, and immunomodulation. Moreover, tumor-infiltration by MCs has been reported in early-stage UBC patients. This infiltration is linked with a favorable or unfavorable prognosis depending on the tumor type and location. Despite the discrepancy of MC function in tumor progression, MCs can modify the TME to regulate the immunity and infiltration of tumors by producing an array of mediators. Nonetheless, the precise role of MCs in UBC tumor progression and evolution remains unknown. Thus, this review discusses some critical roles of MCs in UBC. Patients with UBC are treated at both early and late stages by immunotherapeutic methods, including intravenous bacillus Calmette-Guerin instillation and immune checkpoint blockade. An understanding of the patient response and resistance mechanisms in UBC is required to unlock the complete potential of immunotherapy. Since MCs are pivotal to understand the underlying processes and predictors of therapeutic responses in UBC, our review also focuses on possible immunotherapeutic treatments that involve MCs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | BACILLUS-CALMETTE-GUERIN | - |
dc.subject | REGIONAL ARTERIAL INFUSION | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | NAFAMOSTAT MESILATE | - |
dc.subject | MITOMYCIN-C | - |
dc.subject | TGF-BETA | - |
dc.subject | INFLAMMATION | - |
dc.subject | ANTIBODY | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | ANGIOGENESIS | - |
dc.title | Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Hae Woong | - |
dc.identifier.doi | 10.3390/biomedicines9111500 | - |
dc.identifier.scopusid | 2-s2.0-85118356689 | - |
dc.identifier.wosid | 000723788100001 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, v.9, no.11 | - |
dc.relation.isPartOf | BIOMEDICINES | - |
dc.citation.title | BIOMEDICINES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | BACILLUS-CALMETTE-GUERIN | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MITOMYCIN-C | - |
dc.subject.keywordPlus | NAFAMOSTAT MESILATE | - |
dc.subject.keywordPlus | REGIONAL ARTERIAL INFUSION | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordAuthor | bladder cancer | - |
dc.subject.keywordAuthor | mast cells | - |
dc.subject.keywordAuthor | mucosal immune barrier | - |
dc.subject.keywordAuthor | pro-tumor immunity immunotherapy | - |
dc.subject.keywordAuthor | tumor microenvironment | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.