B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction
DC Field | Value | Language |
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dc.contributor.author | Oh, Younseo | - |
dc.contributor.author | Park, Robin | - |
dc.contributor.author | Kim, So Yeon | - |
dc.contributor.author | Park, Sung-ho | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.date.accessioned | 2022-02-16T20:41:08Z | - |
dc.date.available | 2022-02-16T20:41:08Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-10-20 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136021 | - |
dc.description.abstract | While their function, as immune checkpoint molecules, is well known, B7-family proteins also function as regulatory molecules in bone remodeling. B7-H3 is a receptor ligand of the B7 family that functions primarily as a negative immune checkpoint. While the regulatory function of B7-H3 in osteoblast differentiation has been established, its role in osteoclast differentiation remains unclear. Here we show that B7-H3 is highly expressed in mature osteoclasts and that B7-H3 deficiency leads to the inhibition of osteoclastogenesis in human osteoclast precursors (OCPs). High-throughput transcriptomic analyses reveal that B7-H3 inhibition upregulates IFN signaling as well as IFN-inducible genes, including IDO. Pharmacological inhibition of type-I IFN and IDO knockdown leads to reversal of B7-H3-deficiency-mediated osteoclastogenesis suppression. Although synovial-fluid macrophages from rheumatoid-arthritis patients express B7-H3, inhibition of B7-H3 does not affect their osteoclastogenesis. Thus, our findings highlight B7-H3 as a physiologic positive regulator of osteoclast differentiation and implicate type-I IFN-IDO signaling as its downstream mechanism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | T-CELLS | - |
dc.subject | INDOLEAMINE 2,3-DIOXYGENASE | - |
dc.subject | INFLAMMATORY RESPONSE | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | BONE | - |
dc.subject | LIGAND | - |
dc.subject | IMMUNE | - |
dc.subject | EXPRESSION | - |
dc.title | B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.identifier.doi | 10.1038/s41419-021-04275-6 | - |
dc.identifier.scopusid | 2-s2.0-85117682472 | - |
dc.identifier.wosid | 000709405900001 | - |
dc.identifier.bibliographicCitation | CELL DEATH & DISEASE, v.12, no.11 | - |
dc.relation.isPartOf | CELL DEATH & DISEASE | - |
dc.citation.title | CELL DEATH & DISEASE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | INDOLEAMINE 2,3-DIOXYGENASE | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | T-CELLS | - |
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