Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion
DC Field | Value | Language |
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dc.contributor.author | Mun, Se Hwan | - |
dc.contributor.author | Bae, Seyeon | - |
dc.contributor.author | Zeng, Steven | - |
dc.contributor.author | Oh, Brian | - |
dc.contributor.author | Chai, Carmen | - |
dc.contributor.author | Kim, Matthew Jundong | - |
dc.contributor.author | Kim, Haemin | - |
dc.contributor.author | Kalliolias, George | - |
dc.contributor.author | Dahia, Chitra Lekha | - |
dc.contributor.author | Oh, Younseo | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Park-Min, Kyung-Hyun | - |
dc.date.accessioned | 2022-02-16T20:41:23Z | - |
dc.date.available | 2022-02-16T20:41:23Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-10-20 | - |
dc.identifier.issn | 2095-4700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136022 | - |
dc.description.abstract | Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion. Macrophage colony stimulating factor (M-CSF) is abundant in rheumatoid arthritis (RA). However, the role of M-CSF in arthritic bone erosion is not completely understood. Here, we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS, a receptor for M-CSF, leading to the generation of FMS intracellular domain (FICD) fragments. Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses. Moreover, myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model. The FICD formed a complex with DAP5, and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATc1 protein expression. Moreover, targeting the MNK1/2 pathway diminished arthritic bone erosion. These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | TRANSLATION INITIATION | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | CALPAIN | - |
dc.subject | INFLAMMATION | - |
dc.subject | DEGRADATION | - |
dc.subject | MECHANISMS | - |
dc.subject | RECEPTOR | - |
dc.subject | DISEASE | - |
dc.subject | PROGRESSION | - |
dc.title | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.identifier.doi | 10.1038/s41413-021-00162-0 | - |
dc.identifier.scopusid | 2-s2.0-85117715758 | - |
dc.identifier.wosid | 000709352500001 | - |
dc.identifier.bibliographicCitation | BONE RESEARCH, v.9, no.1 | - |
dc.relation.isPartOf | BONE RESEARCH | - |
dc.citation.title | BONE RESEARCH | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.subject.keywordPlus | CALPAIN | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | TRANSLATION INITIATION | - |
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