Clinical significance of lactate clearance in patients with cardiogenic shock: results from the RESCUE registry
DC Field | Value | Language |
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dc.contributor.author | Park, Ik Hyun | - |
dc.contributor.author | Yang, Jeong Hoon | - |
dc.contributor.author | Jang, Woo Jin | - |
dc.contributor.author | Chun, Woo Jung | - |
dc.contributor.author | Oh, Ju Hyeon | - |
dc.contributor.author | Park, Yong Hwan | - |
dc.contributor.author | Ko, Young-Guk | - |
dc.contributor.author | Yu, Cheol Woong | - |
dc.contributor.author | Kim, Bum Sung | - |
dc.contributor.author | Kim, Hyun-Joong | - |
dc.contributor.author | Lee, Hyun Jong | - |
dc.contributor.author | Jeong, Jin-Ok | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.date.accessioned | 2022-02-16T22:41:04Z | - |
dc.date.available | 2022-02-16T22:41:04Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-10-18 | - |
dc.identifier.issn | 2052-0492 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136032 | - |
dc.description.abstract | Background: Limited data are available on the clinical significance of lactate clearance (LC) in patients with cardiogenic shock (CS). This study investigated the prognostic role of LC in CS patients. Methods: We analyzed data from 628 patients in the RESCUE registry, a multicenter, observational cohort enrolled between January 2014 and December 2018. Univariable logistic regression analysis was performed to determine the prognostic implications of 24 h LC, and then patients were divided into two groups according to the cut-off value of 24 h LC (high lactate clearance [HLC] group vs. low lactate clearance [LLC] group). The primary outcome was in-hospital mortality. We also assessed all-cause mortality at 12 month follow-up and compared the prognostic performance of 24 h LC according to initial serum lactate level. Results: In the univariable logistic regression analysis, 24 h LC was associated with in-hospital mortality (odds ratio 0.989, 95% confidence interval [CI] 0.985-0.993, p < 0.001), and the cut-off value for the LC of the study population was 64%. The HLC group (initial 24 h LC >= 64%, n = 333) had a significantly lower incidence of in-hospital death than the LLC group (n = 295) (25.5% in the HLC group vs. 42.7% in the LLC group, p < 0.001). During 12 months of follow-up, the cumulative incidence of all-cause death was significantly lower in the HLC group than in the LLC group (33.0% vs. 48.8%; hazard ratio 0.55; 95% CI 0.42-0.70; p < 0.001). In subgroup analysis, 24 h LC predicted in-hospital mortality better in patients with initial serum lactate > 5 mmol/L than in those with serum lactate <= 5 mmol/L (c-statistics of initial serum lactate > 5 mmol/L = 0.782 vs. c-statistics of initial serum lactate <= 5 mmol/L = 0.660, p = 0.011). Conclusions: Higher LC during the early phase of CS was associated with reduced risk of in-hospital and 12 month all-cause mortalities. Patients with LC >= 64% during the 24 h after CS onset could expect a favorable prognosis, especially those with an initial serum lactate > 5 mmol/L. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | EXTRACORPOREAL MEMBRANE-OXYGENATION | - |
dc.subject | SEVERE SEPSIS | - |
dc.subject | MULTICENTER | - |
dc.subject | OUTCOMES | - |
dc.subject | THERAPY | - |
dc.subject | SUPPORT | - |
dc.title | Clinical significance of lactate clearance in patients with cardiogenic shock: results from the RESCUE registry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yu, Cheol Woong | - |
dc.identifier.doi | 10.1186/s40560-021-00571-7 | - |
dc.identifier.scopusid | 2-s2.0-85117446569 | - |
dc.identifier.wosid | 000708470100001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INTENSIVE CARE, v.9, no.1 | - |
dc.relation.isPartOf | JOURNAL OF INTENSIVE CARE | - |
dc.citation.title | JOURNAL OF INTENSIVE CARE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.subject.keywordPlus | EXTRACORPOREAL MEMBRANE-OXYGENATION | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | SUPPORT | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Cardiogenic shock | - |
dc.subject.keywordAuthor | Lactate clearance | - |
dc.subject.keywordAuthor | Prognosis | - |
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