Access to the Triplet Excited States of Heavy-Atom-Free Boron-Dipyrromethene Photosensitizers via Radical Pair Intersystem Crossing for Image-Guided Tumor-Targeted Photodynamic Therapy
DC Field | Value | Language |
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dc.contributor.author | Van-Nghia Nguyen | - |
dc.contributor.author | Ha, Jeongsun | - |
dc.contributor.author | Koh, Chang Woo | - |
dc.contributor.author | Ryu, Bokyeong | - |
dc.contributor.author | Kim, Gyoungmi | - |
dc.contributor.author | Park, Jae Hak | - |
dc.contributor.author | Kim, C-Yoon | - |
dc.contributor.author | Park, Sungnam | - |
dc.contributor.author | Yoon, Juyoung | - |
dc.date.accessioned | 2022-02-17T03:40:23Z | - |
dc.date.available | 2022-02-17T03:40:23Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021-10-12 | - |
dc.identifier.issn | 0897-4756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136055 | - |
dc.description.abstract | Boron- dipyrromethene (BODIPY) dyes have aroused considerable interest in cancer theranostics over the past decade because of robust photochemical properties. Although a large number of BODIPY photosensitizers (PSs) containing heavy atoms have been reported, the development of heavy-atom-free BODIPY PSs for oncologic photodynamic therapy (PDT) has been limited mainly by the uncertainty in intersystem crossing (ISC) mechanisms, unbalanced phototoxic effectiveness and fluorescence quantum yields, and aggregation-caused quenching effects. In addition, the lack of extensive in vivo studies of heavyatom-free BODIPY PSs continues to limit clinical application. Herein, novel heavy-atom-free BODIPY-phenoxazine triads (BDP-8/BDP-9) that generate efficient excited triplet states via radical pair intersystem crossing (RP-ISC) followed by triplet charge recombination were developed for use in fluorescence image-guided PDT. BDP-8/BDP-9 exhibited high molar absorption coefficients, prominent aggregation-induced emission, and excellent singlet oxygen generation capability upon light irradiation. The corresponding BODIPY nanoparticles (BDP-8/BDP-9 NPs) with bright red emission, considerable phototoxicity, and excellent tumor-targeting ability were simply prepared by encapsulating BDP-8/BDP-9 PSs in a polymeric matrix. More importantly, the results of both in vitro and in vivo experiments demonstrated the considerable potential of BDP-8 NPs for image-guided photodynamic cancer therapy. This study may inspire the development of potential BODIPY-based nanoagents for cancer theranostics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | MOLECULAR DESIGN | - |
dc.subject | SINGLET OXYGEN | - |
dc.subject | HIGHLY EFFICIENT | - |
dc.subject | GENERATION | - |
dc.subject | HYPOXIA | - |
dc.title | Access to the Triplet Excited States of Heavy-Atom-Free Boron-Dipyrromethene Photosensitizers via Radical Pair Intersystem Crossing for Image-Guided Tumor-Targeted Photodynamic Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungnam | - |
dc.identifier.doi | 10.1021/acs.chemmater.1c02776 | - |
dc.identifier.scopusid | 2-s2.0-85117138720 | - |
dc.identifier.wosid | 000708647800030 | - |
dc.identifier.bibliographicCitation | CHEMISTRY OF MATERIALS, v.33, no.19, pp.7889 - 7896 | - |
dc.relation.isPartOf | CHEMISTRY OF MATERIALS | - |
dc.citation.title | CHEMISTRY OF MATERIALS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 7889 | - |
dc.citation.endPage | 7896 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | MOLECULAR DESIGN | - |
dc.subject.keywordPlus | SINGLET OXYGEN | - |
dc.subject.keywordPlus | HIGHLY EFFICIENT | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | HYPOXIA | - |
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